Stomach cancer, also known as gastric cancer, is the fifth-leading type of cancer and the third-leading cause of death from cancer, making up 9% of global mortality rate. The major treatment for advanced stomach cancer is a combination of neoadjuvant radiotherapy, targeted therapy, and immunotherapy, using classical targets such as PD-1/PD-L1, HER-2, and VEGF/VEGFR, as well as the novel target Claudin18.2. Claudin18.2 has been demonstrated to be highly limited in normal tissues and abnormally expressed in various tumor types' main and metastatic foci (e.g., stomach cancer, pancreatic cancer, bile duct cancer). Antibodies can bind to Claudin18.2 on the extracellular membrane, where it plays a role in tumorigenesis and progression.
GemPharmatech has a collection of 39 stomach cancer PDXs some of which express Claudin18.2. These PDXs can be used to evaluate the preclinical efficacy of antibody drugs, ADCs, cell therapy, and other treatments targeting Claudin18.2.
At present, GemPharmatech' extensive collection possesses 43 cases of PDX tumor samples of Stomach cancer.
PDX ID | Histological type | Grade | Stage | WES | RNA-seq |
SC00303 | Adenocarcinoma | Low to medium differentiation | N/A | Y | Y |
Adenocarcinoma | Moderately differentiated | N/A | Y | Y | |
SC00312 | Adenocarcinoma | Poorly differentiated | Ⅲa(pT4aN1M0) | Y | Y |
SC00314 | N/A | N/A | N/A | Y | Y |
SC00332 | Adenocarcinoma | Poorly differentiated | N/A | Y | Y |
SC00336 | Adenocarcinoma | Low to medium differentiation | pT2N0M0 ⅠB | Y | Y |
SC00344 | Adenocarcinoma | Moderately differentiated | ⅢB(pT4aN0M0) | Y | Y |
SC00347 | Adenocarcinoma | Moderately differentiated | Ⅳ(T3NXM1) | N/A | Y |
Adenocarcinoma | Poorly differentiated | T4aN3aM0 | Y | N/A | |
SC00384 | Adenocarcinoma | Low to medium differentiation | N/A | Y | Y |
SC00400 | Adenocarcinoma | Poorly differentiated | Ⅳ | Y | Y |
SC00429 | N/A | N/A | N/A | Y | Y |
SC00436 | N/A | N/A | N/A | N/A | Y |
SC00439 | N/A | N/A | N/A | N/A | Y |
SC00485 | N/A | N/A | N/A | Y | Y |
SC00488 | N/A | N/A | N/A | Y | Y |
SC00529 | Adenocarcinoma | Poorly differentiated | Ⅳ | N/A | N/A |
SC00548 | N/A | N/A | N/A | N/A | Y |
SC00549 | Adenocarcinoma | Moderately differentiated | Ⅳ | N/A | Y |
SC00558 | N/A | Moderately differentiated | Ⅳ | Y | Y |
SC00620 | N/A | N/A | ⅢA | Y | Y |
SC00630 | N/A | N/A | N/A | Y | Y |
SC00705 | Adenocarcinoma | N/A | N/A | Y | Y |
SC00708 | Adenocarcinoma | N/A | N/A | Y | Y |
SC00712 | Adenocarcinoma | N/A | N/A | Y | Y |
SC00713 | Adenocarcinoma | N/A | N/A | Y | Y |
SC00714 | Adenocarcinoma | N/A | N/A | Y | Y |
SC00715 | Adenocarcinoma | N/A | N/A | Y | Y |
SC00716 | Adenocarcinoma | Poorly differentiated | N/A | Y | Y |
SC00717 | N/A | N/A | Ⅲ | Y | Y |
SC00720 | N/A | N/A | N/A | Y | Y |
SC00726 | N/A | N/A | N/A | Y | Y |
SC00728 | N/A | N/A | N/A | Y | Y |
SC00730 | N/A | N/A | N/A | Y | Y |
SC00733 | N/A | N/A | N/A | Y | Y |
SC00735 | N/A | N/A | N/A | Y | Y |
SC00748 | N/A | N/A | N/A | Y | Y |
SC00752 | N/A | N/A | N/A | Y | Y |
SC00753 | N/A | N/A | N/A | Y | Y |
SC00754 | N/A | N/A | N/A | Y | Y |
SC00760 | N/A | N/A | N/A | N/A | Y |
SC00761 | N/A | N/A | N/A | N/A | Y |
SC00763 | N/A | N/A | N/A | N/A | Y |