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Stomach Cancer PDX

Stomach cancer, also known as gastric cancer, is the fifth-leading type of cancer and the third-leading cause of death from cancer, making up 9% of global mortality rate. The major treatment for advanced stomach cancer is a combination of neoadjuvant radiotherapy, targeted therapy, and immunotherapy, using classical targets such as PD-1/PD-L1, HER-2, and VEGF/VEGFR, as well as the novel target Claudin18.2. Claudin18.2 has been demonstrated to be highly limited in normal tissues and abnormally expressed in various tumor types' main and metastatic foci (e.g., stomach cancer, pancreatic cancer, bile duct cancer). Antibodies can bind to Claudin18.2 on the extracellular membrane, where it plays a role in tumorigenesis and progression.

GemPharmatech has a collection of 39 stomach cancer PDXs some of which express Claudin18.2. These PDXs can be used to evaluate the preclinical efficacy of antibody drugs, ADCs, cell therapy, and other treatments targeting Claudin18.2.

 

At present, GemPharmatech' extensive collection possesses 43 cases of PDX tumor samples of Stomach  cancer.

      PDX ID         

            Histological type       

                    Grade                 

                   Stage                   

     WES     

    RNA-seq     

SC00303

Adenocarcinoma

Low to medium differentiation

N/A

Y

Y

SC00309

Adenocarcinoma

Moderately differentiated

N/A

Y

Y

SC00312

Adenocarcinoma

Poorly differentiated

Ⅲa(pT4aN1M0)

Y

Y

SC00314

N/A

N/A

N/A

Y

Y

SC00332

Adenocarcinoma

Poorly differentiated

N/A

Y

Y

SC00336

Adenocarcinoma

Low to medium differentiation

pT2N0M0 ⅠB

Y

Y

SC00344

Adenocarcinoma

Moderately differentiated

ⅢB(pT4aN0M0)

Y

Y

SC00347

Adenocarcinoma

Moderately differentiated

Ⅳ(T3NXM1)

N/A

Y

SC00352

Adenocarcinoma

Poorly differentiated

T4aN3aM0

Y

N/A

SC00384

Adenocarcinoma

Low to medium differentiation

N/A

Y

Y

SC00400

Adenocarcinoma

Poorly differentiated

Ⅳ

Y

Y

SC00429

N/A

N/A

N/A

Y

Y

SC00436

N/A

N/A

N/A

N/A

Y

SC00439

N/A

N/A

N/A

N/A

Y

SC00485

N/A

N/A

N/A

Y

Y

SC00488

N/A

N/A

N/A

Y

Y

SC00529

Adenocarcinoma

Poorly differentiated

Ⅳ

N/A

N/A

SC00548

N/A

N/A

N/A

N/A

Y

SC00549

Adenocarcinoma

Moderately differentiated

Ⅳ

N/A

Y

SC00558

N/A

Moderately differentiated

Ⅳ

Y

Y

SC00620

N/A

N/A

ⅢA

Y

Y

SC00630

N/A

N/A

N/A

Y

Y

SC00705

Adenocarcinoma

N/A

N/A

Y

Y

SC00708

Adenocarcinoma

N/A

N/A

Y

Y

SC00712

Adenocarcinoma

N/A

N/A

Y

Y

SC00713

Adenocarcinoma

N/A

N/A

Y

Y

SC00714

Adenocarcinoma

N/A

N/A

Y

Y

SC00715

Adenocarcinoma

N/A

N/A

Y

Y

SC00716

Adenocarcinoma

Poorly differentiated

N/A

Y

Y

SC00717

N/A

N/A

Ⅲ

Y

Y

SC00720

N/A

N/A

N/A

Y

Y

SC00726

N/A

N/A

N/A

Y

Y

SC00728

N/A

N/A

N/A

Y

Y

SC00730

N/A

N/A

N/A

Y

Y

SC00733

N/A

N/A

N/A

Y

Y

SC00735

N/A

N/A

N/A

Y

Y

SC00748

N/A

N/A

N/A

Y

Y

SC00752

N/A

N/A

N/A

Y

Y

SC00753

N/A

N/A

N/A

Y

Y

SC00754

N/A

N/A

N/A

Y

Y

SC00760

N/A

N/A

N/A

N/A

Y

SC00761

N/A

N/A

N/A

N/A

Y

SC00763

N/A

N/A

N/A

N/A

Y


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