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BKS-Leprem2Cd479/Gpt
BKS-db|Strain
NO.T002407
Knockout (KO)
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BKS-Leprem2Cd479/Gpt
BKS-db|Strain
NO.T002407
Knockout (KO)
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周 龄
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- 基本信息
- 品系说明：1）血糖特点 BKS-db 4~8 W为血糖快速升高期，该期间小鼠血糖浮动范围较广，不同个体间的血糖差异也较大，如果采用此周龄段的小鼠进行实验，建议实验前严格测血糖分组，且实验结果可能会有一定的误差。8W以后血糖值渐渐趋于一致，但仍然存在个体差异导致血糖不均一的情况，建议增加20%~30%的富余量。发病标准:空腹血糖>11.1mmol/l，随机血糖>16.7mmol/l。环境刺激、小鼠状态、测量时间及饱腹程度（禁食时间）等都会影响血糖测定。建议饲养在屏障设施中，保证饮水和饮食充足，勤换垫料，减少应激，统一测血糖时间和采血方式，接收到小鼠后进行1~2周适应性饲养再实验。禁食血糖空腹一般不超过6h。 2）糖肾特点 一般情况下，部分小鼠在16W开始出现严重的肾脏并发症，表现为肾脏组织粘连，无法取出完整肾脏做病理学检测或小鼠死亡的情况。部分血糖较高小鼠可能会在12W左右出现类似严重肾脏并发症。如进行血糖相关研究，建议在实际入组数量的基础上额外增加20%~30%以上的富余量，或者选择较早周龄取材。一般对于肾脏病变的评价指标有病理切片、血生化和尿生化，其中尿生化数据是相对最不稳定的，建议结合其他两项检测来进行判断。如进行糖肾相关研究，需严格设置入组指标，选择合适的小鼠入组实验。另外，易出现批次间差异，建议批次内比较。
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000214] C57BLKS/JGpt
- 微生物等级： SPF级
- 研究领域：疾病与药物评价模型,代谢模型,糖尿病模型,肥胖模型
- 领域描述：1.II型糖尿病研究和肥胖症的研究2.内分泌缺陷研究3.代谢研究4.生殖生物学研究。
- 发表文献：
Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice https://doi.org/10.1038/s41467-023-35944-z Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome https://doi.org/10.1016/j.phymed.2022.154308 Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice https://doi.org/10.1016/j.phymed.2022.154316 Inulin-Type Fructans Change the Gut Microbiota and Prevent the Development of Diabetic Nephropathy https://doi.org/10.1016/j.phrs.2022.106367 Hepatic leptin signaling improves hyperglycemia by stimulating MAPK phosphatase-3 protein degradation via STAT3 https://doi.org/10.1016/j.jcmgh.2022.07.010 A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice https://doi.org/10.1016/j.bbrc.2022.07.031 m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin https://doi.org/10.1080/15548627.2021.1974175 Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation https://doi.org/10.1016/j.apsb.2021.11.017 Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus https://doi.org/10.1016/j.freeradbiomed.2021.08.240 VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy https://doi.org/10.2337/db21-0205 Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism https://doi.org/10.1016/j.cmet.2020.11.017 Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy https://doi.org/10.1016/j.biopha.2021.111780 MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice https://doi.org/10.1016/j.metabol.2021.154768 Human foreskin-derived dermal stem/progenitor cell-conditioned medium combined with hyaluronic acid promotes extracellular matrix regeneration in diabetic wounds https://doi.org/10.1186/s13287-020-02116-5 High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy https://doi.org/10.1038/s41419-021-03502-4 Cdk5-mediated phosphorylation of Sirt1 contributes to podocyte mitochondrial dysfunction in diabetic nephropathy https://doi.org/10.1089/ars.2020.8038 Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging https://doi.org/10.1021/acs.analchem.1c00498 circRNA_010383 acts as a sponge for miR-135a, and its downregulated expression contributes to renal fibrosis in diabetic nephropathy https://doi.org/10.2337/db20-0203 A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis https://doi.org/10.1016/j.ebiom.2020.103202 CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis https://doi.org/10.1016/j.biomaterials.2021.120963 RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation https://doi.org/10.1155/2021/6617816 Purβ promotes hepatic glucose production by increasing Adcy6 transcription https://doi.org/10.1016/j.molmet.2019.11.008 Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo https://doi.org/10.1002/advs.202000818 SIK2 protects against renal tubular injury and the progression of diabetic kidney disease http://doi.org/10.1016/j.trsl.2022.08.012 A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice http://doi.org/10.1016/j.actbio.2022.10.038 Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation http://doi.org/10.1002/advs.202202590 Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes https://doi.org/10.1007/s00125-022-05822-2 ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation https://doi.org/10.1016/j.redox.2022.102554 Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction https://doi.org/10.1016/j.omtn.2022.12.009 THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass https://doi.org/10.1038/s41467-023-36680-0 Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing https://doi.org/10.1016/j.xcrm.2023.101129 A novel mouse model of heart failure with preserved ejection fraction after chronic kidney disease induced by retinol through JAK/STAT pathway https://doi.org/10.7150/ijbs.83432 Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum https://doi.org/10.1186/s12944-023-01880-6 Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro https://doi.org/10.1021/acsomega.3c03513 mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1 https://doi.org/10.1038/s42255-022-00536-6 Identification and validation of voltage-dependent anion channel 1-related genes and immune cell infiltration in diabetic nephropathy https://doi.org/10.1111/jdi.14087 Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice https://doi.org/10.1186/s12872-023-03485-4 Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice https://doi.org/10.32604/biocell.2023.024944 Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component systemnasal colonized S. aureus in type 2 diabetes https://doi.org/10.1080/22221751.2023.2276335 Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice https://doi.org/10.1016/j.biopha.2023.115660 Lentinan alleviates diabetic cardiomyopathy by suppressing CAV1/SDHA-regulated mitochondrial dysfunction https://doi.org/10.1016/j.biopha.2023.115645 Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7 https://doi.org/10.1016/j.biopha.2023.115747 Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease https://doi.org/10.1016/j.cmet.2022.10.002 Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1 https://doi.org/10.1007/s00018-023-04802-y ApoSEVs-Mediated Modulation of Versatile Target Cells Promotes Diabetic Wound Healing: Unveiling a Promising Strategy https://doi.org/10.2147/IJN.S436350 Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis https://doi.org/10.1016/j.apsb.2023.11.020 Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus https://doi.org/10.1016/j.bioactmat.2023.10.022 Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction https://doi.org/10.1038/s12276-023-01112-y Nephropathy Is Aggravated by Fatty Acids in Diabetic Kidney Disease through Tubular Epithelial Cell Necroptosis and Is Alleviated by an RIPK-1 Inhibitor https://doi.org/10.1159/000529995 Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy https://doi.org/10.1080/15548627.2023.2286128 Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice https://doi.org/10.4239/wjd.v14.i12.1824 Fatty acid beta-oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice https://doi.org/10.1111/1753-0407.13458 Pancreatic Cancer: An Exocrine Tumor with Endocrine Characteristics https://doi.org/10.1097/SLA.0000000000006168 Sodium butyrate improves mitochondrial function and kidney tissue injury in diabetic kidney disease via the AMPK/PGC-1alpha pathway https://doi.org/10.1080/0886022X.2023.2287129 Targeting YAP1-regulated Glycolysis in Fibroblast-Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression https://doi.org/10.1002/advs.202304617 MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease https://doi.org/10.2147/DMSO.S441082 The Synergism of Human Lactobacillaceae and Inulin Decrease Hyperglycemia via Regulating the Composition of Gut Microbiota and Metabolic Profiles in db/db Mice https://doi.org/10.4014/jmb.2304.04039 Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding https://doi.org/10.1111/bph.16288 Early detection of cardiac fibrosis in diabetic mice by targeting myocardiopathy and matrix metalloproteinase 2 https://doi.org/10.1016/j.actbio.2024.01.017 Ultrasound Deep Brain Stimulation Regulates Food Intake and Body Weight in Mice https://doi.org/10.1109/TNSRE.2024.3351312 Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism https://doi.org/10.1002/advs.202306365 Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component system https://doi.org/10.1080/22221751.2023.2276335 (Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway https://doi.org/10.1186/s12967-023-04846-5 Aged oolong tea manages type 2 diabetes mellitus by inhibiting fat ectopic deposition and alleviating insulin resistance in db/db mice https://doi.org/10.1002/fft2.338 Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor) https://doi.org/10.1038/s41392-023-01727-7 Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy https://doi.org/10.2147/DMSO.S443352 The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice https://doi.org/10.1016/j.isci.2024.109134 Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway https://doi.org/10.1016/j.jep.2024.117829 Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice https://doi.org/10.1186/s13098-024-01270-7 Compound Danshen dripping pills prevent early diabetic retinopathy: roles of vascular protection and neuroprotection https://doi.org/10.3389/fphar.2024.1294620 Trimethylamine N-oxide impairs beta-cell function and glucose tolerance https://doi.org/10.1007/s00432-024-05693-7 VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy https://doi.org/10.1002/advs.202305563 MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus https://doi.org/10.1186/s12933-024-02178-2 Assessment of Reference Genes Stability in Cortical Bone of Obese and Diabetic Mice https://doi.org/10.2147/DMSO.S453458 PPARalpha/delta dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells https://doi.org/10.1016/j.bcp.2024.116076 Label-free analysis of the beta-hydroxybutyricacid drug on mitochondrial redox states repairment in type 2 diabetic mice by resonance raman scattering https://doi.org/10.1016/j.biopha.2024.116320 Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes https://doi.org/10.1016/j.heliyon.2024.e27618 Noninvasive Monitoring of Early Cardiac Fibrosis in Diabetic Mice by [(68)Ga]Ga-DOTA-FAPI-04 PET/CT Imaging https://doi.org/10.1021/acsomega.3c10061 Replenishment of mitochondrial Na(+) and H(+) by ionophores potentiates cutaneous wound healing in diabetes https://doi.org/10.1016/j.mtbio.2024.101056 Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate https://doi.org/10.1021/acsnanoscienceau.3c00035 Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy https://doi.org/10.1111/apha.14159 CHILKBP protects against podocyte injury by preserving ZO-1 expression https://doi.org/10.1007/s00018-022-04661-z Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy https://doi.org/10.1016/j.isci.2024.109796 Pinctada martensii Hydrolysate Modulates the Brain Neuropeptidome and Proteome in Diabetic (db/db) Mice via the Gut–Brain Axis https://doi.org/10.3390/md22060249 Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis https://doi.org/10.1016/j.bioactmat.2024.04.019 The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair https://doi.org/10.1016/j.cmet.2024.05.005 Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption https://doi.org/10.1038/s42255-024-01072-1 Inhibition of endoplasmic reticulum stress and excessive autophagy by Jiedu Tongluo Tiaogan Formula via a CaMKKbeta/AMPK pathway contributes to protect pancreatic beta-cells https://doi.org/10.1016/j.jep.2024.118440 Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway https://doi.org/10.1016/j.redox.2024.103246 Plasma Asprosin Concentrations are Associated with Progression of Diabetic Kidney Disease https://doi.org/10.2147/DMSO.S447465 Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice https://doi.org/10.4093/dmj.2023.0109 A neural-mast cell axis regulates skin microcirculation in diabetes https://doi.org/10.2337/db23-0862/769709/db230862.pdf
*使用本品系发表的文献需注明：BKS-db mice（Strain NO.T002407）were purchased from GemPharmatech (Nanjing, China).
