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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain
NO.T001475
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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
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NO.T001475
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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
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NO.T001475
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NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt
NCG|Strain
NO.T001475
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周 龄
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- 基本信息
- 基因官方名：Prkdc,Il2rg
- 基因全名：protein kinase DNA activated catalytic polypeptide,interleukin 2 receptor gamma chain
- 基因别名：AI326420,AU019811,DNA-PKcs,DNAPDcs,DNAPK,DNPK1,DOXNPH,HYRC1,XRCC7,dxnph,p460
- NCBI：19090#16186
- MGI：104779#96551
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000235] NOD/ShiLtJGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T001475.NCG strain info.pdf T001475.NCG 品系资料.pdf
- 研究领域：人源化模型
- 领域描述：1.人源免疫重建小鼠模型，如BLT人源化小鼠.PBMC人源化小鼠及CD34+人源化小鼠;2.人源肿瘤细胞.肿瘤组织移植(CDX，PDX);3.药效评价(小分子.大分子.联合用药);4.人类癌症模型;5.干细胞研究。
- 发表文献：
Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment https://doi.org/10.7150/thno.79367 Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling https://doi.org/10.1002/advs.202100914 Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML https://doi.org/10.1016/j.cmet.2022.04.004 Biomimetic Nanoerythrosome‐Coated Aptamer‐DNA Tetrahedron/Maytansine Conjugates: pH‐Responsive and Targeted Cytotoxicity for HER2‐positive Breast Cancer https://doi.org/10.1002/adma.202109609 Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment https://doi.org/10.1158/2159-8290.CD-21-1022 Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates https://doi.org/10.1038/s41421-021-00291-0 ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3 https://www.thno.org/v11p0841.htm Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1 https://doi.org/10.1002/ctm2.449 Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling https://doi.org/10.1038/s41422-021-00528-3 Creatine promotes cancer metastasis through activation of Smad2/3 https://doi.org/10.1016/j.cmet.2021.03.009 Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells https://doi.org/10.1158/1078-0432.CCR-21-0452 AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia https://doi.org/10.1038/s41408-021-00508-1 Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors https://doi.org/10.1126/scitranslmed.abb5191 Development of an antibody-like T-cell engager based on VH-VL heterodimer formation and its application in cancer therapy https://doi.org/10.1016/j.biomaterials.2021.120760 The Rational Development of CD5-targeting Biepitopic Chimeric Antigen Receptors with Fully Human Heavy-chain-only Antigen Recognition Domains https://doi.org/10.1016/j.ymthe.2021.07.001 N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression https://doi.org/10.1016/j.molcel.2021.07.003 Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors http://www.thno.org/v10p7622.htm ARID1A hypermethylation disrupts transcriptional homeostasis to promote squamous cell carcinoma progression https://doi.org/10.1158/0008-5472 ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness https://doi.org/10.1038/s41418-019-0475-6 Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy https://www.science.org/doi/10.1126/scitranslmed.aaz6667 Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging https://doi.org/10.7150/thno.36545 Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study http://doi.org/10.1038/s41422-022-00721-y OXTR(High) stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling http://doi.org/10.1038/s41467-022-32787-y Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL http://doi.org/10.1038/s41586-022-05140-y Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer http://doi.org/10.1016/j.ccell.2022.08.010 Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma http://doi.org/10.1186/s13045-022-01359-4 Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy http://doi.org/10.1136/jitc-2022-004790 Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance https://doi.org/10.1016/j.jare.2022.11.006 Hook&Loop multivalent interactions based on disk-shaped nanoparticles strengthen active targeting https://doi.org/10.1016/j.jconrel.2023.01.022 Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy https://doi.org/10.1136/jitc-2022-005986 BPA‐Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model https://doi.org/10.1002/adfm.202214145 Anti-BCMA surface engineered biomimetic photothermal nanomissile enhances multiple myeloma cell apoptosis and overcomes the disturbance of NF-kappaB signaling in vivo https://doi.org/10.1016/j.biomaterials.2023.122096 EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1 https://doi.org/10.1038/s41467-023-37954-3 Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche https://doi.org/10.3389/fimmu.2023.1157027 Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma https://doi.org/10.7150/thno.82140 PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance https://doi.org/10.1126/sciadv.ade4186 Impaired histone inheritance promotes tumor progression https://doi.org/10.1038/s41467-023-39185-y NOTCH4(DeltaL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1 https://doi.org/10.1038/s41467-023-38833-7 Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/beta-catenin positive feedback loop https://doi.org/10.1016/j.jare.2023.05.012 GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer https://doi.org/10.1186/s13045-023-01467-9 Lenvatinib improves anti-PD-1 therapeutic efficacy by promoting vascular normalization via the NRP-1-PDGFRbeta complex in hepatocellular carcinoma https://doi.org/10.3389/fimmu.2023.1212577 Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment https://doi.org/10.1016/j.omto.2023.07.007 Preconditioning of radiotherapy enhances efficacy of B7-H3-CAR-T in treating solid tumor models https://doi.org/10.1016/j.lfs.2023.122024 Targeted delivery of a PD-1-blocking scFv by CD133-specific CAR-T cells using nonviral Sleeping Beauty transposition shows enhanced antitumour efficacy for advanced hepatocellular carcinoma https://doi.org/10.1186/s12916-023-03016-0 Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma https://doi.org/10.1016/j.isci.2023.107369 Treating solid tumors with TCR-based chimeric antigen receptor targeting extra domain B-containing fibronectin https://doi.org/10.1136/jitc-2023-007199 WDR54 exerts oncogenic roles in T-cell acute lymphoblastic leukemia https://doi.org/10.1111/cas.15872 Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity https://doi.org/10.1038/s41467-023-41101-3 Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells https://doi.org/10.1002/1878-0261.13521 The application of HER2 and CD47 CAR-macrophage in ovarian cancer https://doi.org/10.1186/s12967-023-04479-8 A drug-delivery depot for epigenetic modulation and enhanced cancer immunotherapy https://doi.org/10.1016/j.biopha.2023.115687 A human mucosal melanoma organoid platform for modeling tumor heterogeneity and exploring immunotherapy combination options https://doi.org/10.1126/sciadv.adg668 Intratumoral CD103(+) CD8(+) T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma https://doi.org/10.1002/cac2.12480 Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression https://doi.org/10.1016/j.phrs.2023.106942 The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer https://doi.org/10.1038/s41467-023-42332-0 Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway https://doi.org/10.1038/s41551-023-01073-7 Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity https://doi.org/10.1016/j.celrep.2023.113211 Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models https://doi.org/10.1016/j.tranon.2023.101803 GARP-mediated active TGF-beta1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT https://doi.org/10.1182/blood.2022015474 Long noncoding RNA NONHSAT160169.1 promotes resistance via hsa-let-7c-3p/SOX2 axis in gastric cancer https://doi.org/10.1038/s41598-023-47961-5 Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51 https://doi.org/10.1038/s41467-023-42850-x Tumor-infiltrating platelets promote the growth of lung adenocarcinoma https://doi.org/10.1016/j.tranon.2023.101813 Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway https://doi.org/10.1038/s41419-023-06327-5 Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application https://doi.org/10.1016/j.xcrm.2023.101277 Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma https://doi.org/10.1016/j.cmet.2023.11.019 Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Inhibits FIH-1 Expression to Promote Tumor Angiogenesis in HBV-Related Hepatocellular Carcinoma https://doi.org/10.2147/JHC.S436926 A Near-Infrared-II Fluorescent Nanocatalyst for Enhanced CAR T Cell Therapy against Solid Tumor by Immune Reprogramming https://doi.org/10.1021/acsnano.3c02592 Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity https://doi.org/10.1002/iid3.1143 IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects https://doi.org/10.1016/j.isci.2023.108597 FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2alpha blockade by facilitating LDHA phosphorylation https://doi.org/10.1038/s41419-024-06450-x Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting https://doi.org/10.1016/j.eng.2024.01.001 Cell-Surface GRP78-Targeted Chimeric Antigen Receptor T Cells Eliminate Lung Cancer Tumor Xenografts https://doi.org/10.3390/ijms25010564 An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL) https://doi.org/10.3390/biom14010106 Effects of methionine deficiency on B7H3-DAP12-CAR-T cells in the treatment of lung squamous cell carcinoma https://doi.org/10.1038/s41419-023-06376-w Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis https://doi.org/10.1186/s13075-024-03271-3 RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9 https://doi.org/10.1186/s13059-023-03149-8 A trispecific antibody induces potent tumor-directed T-cell activation and antitumor activity by CD3/CD28 co-engagement https://doi.org/10.2217/imt-2023-0256 MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma https://doi.org/10.1038/s41419-024-06490-3 RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis https://doi.org/10.1016/j.celrep.2024.113786 High-fat diet promotes prostate cancer metastasis via RPS27 https://doi.org/10.1186/s40170-024-00333-7 CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma https://doi.org/10.1038/s41417-022-00512-y The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments https://doi.org/10.1186/s12943-024-01938-8 RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid https://doi.org/10.1186/s12935-024-03299-0 Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody https://doi.org/10.1038/s44321-024-00026-0 Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer https://doi.org/10.1007/s00262-024-03667-9 Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial https://doi.org/10.1038/s41467-024-47801-8 Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology https://doi.org/10.1186/s12967-024-05159-x DR30318, a novel tri-specific T cell engager for Claudin 18.2 positive cancers immunotherapy https://doi.org/10.1007/s00262-024-03673-x GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer https://doi.org/10.1186/s12915-024-01881-6 ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/beta-catenin/PD-L1 axis https://doi.org/10.1016/j.isci.2024.109533 m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia https://doi.org/10.1002/ctm2.1628 PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer https://doi.org/10.7150/ijbs.82361 PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion https://doi.org/10.1136/jitc-2023-008429 Self-Assembled Multivalent Aptamer Drug Conjugates: Enhanced Targeting and Cytotoxicity for HER2-Positive Gastric Cancer https://doi.org/10.1021/acsami.3c07344 STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells https://doi.org/10.1038/s41419-024-06638-1 Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1 https://doi.org/10.1016/j.gendis.2024.101330 CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival https://doi.org/10.1080/2162402X.2024.2358590 Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes https://doi.org/10.1016/j.biopha.2024.116727 Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2 https://doi.org/10.1021/acs.jmedchem.4c00027 Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps" https://doi.org/10.1016/j.phrs.2024.107221 NCX1/Ca(2+) promotes autophagy and decreases bortezomib activity in multiple myeloma through non-canonical NFkappaB signaling pathway https://doi.org/10.1186/s12964-024-01628-4 Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells https://doi.org/10.1038/s41467-024-48607-4 Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN https://doi.org/10.1186/s12951-024-02505-5 Zebularine potentiates anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through cGAS-STING pathway https://doi.org/10.1038/s42003-024-06271-w An herbal formula Shenlian decoction upregulates M1/M2 macrophage proportion in hepatocellular carcinoma by suppressing complement cascade https://doi.org/10.1016/j.biopha.2024.116943 EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion https://doi.org/10.1136/jitc-2023-008375 Liensinine diperchlorate and artemisitene synergistically attenuate breast cancer progression through suppressing PI3K-AKT signaling and their efficiency in breast cancer patient-derived organoids https://doi.org/10.1016/j.biopha.2024.116871 Preclinical evaluation of cyclophosphamide and fludarabine combined with CD19 CAR-T in the treatment of B-cell hematologic malignancies in vivo https://doi.org/10.32604/or.2024.049792 A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against ban https://doi.org/10.1128/jvi.00769-24 A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis https://doi.org/10.1016/j.drup.2024.101116 A general pHLA-CD80 scaffold fusion protein to promote efficient antigen-specific T cell-based immunotherapy https://doi.org/10.1016/j.omton.2024.200827 Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variants https://doi.org/10.1016/j.isci.2024.110366 N(6)-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor https://doi.org/10.1186/s13046-024-03113-9 Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin https://doi.org/10.1136/jitc-2024-008888 Pancreatic STAT5 activation promotes Kras(G12D)-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancer https://doi.org/10.1136/gutjnl-2024-332225 RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway https://doi.org/10.1038/s41419-024-06866-5 ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8(+) T cells https://doi.org/10.1038/s41467-024-50077-7 An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy https://doi.org/10.1038/s43018-024-00760-x PIM1/NF-kappaB/CCL2 blockade enhances anti-PD-1 therapy response by modulating macrophage infiltration and polarization in tumor microenvironment of NSCLC https://doi.org/10.1038/s41388-024-03100-6 Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE(2) production https://doi.org/10.1016/j.celrep.2024.114469
*使用本品系发表的文献需注明：NCG mice（Strain NO.T001475）were purchased from GemPharmatech (Nanjing, China).
