集萃药康|NCG

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NOD/ShiLtJGpt-Prkdc^em26Cd52Il2rg^em26Cd22/Gpt

NCG|Strain NO.T001475

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基本信息

基因官方名：Prkdc,Il2rg
基因全名：protein kinase DNA activated catalytic polypeptide,interleukin 2 receptor gamma chain
基因别名：AI326420,AU019811,DNA-PKcs,DNAPDcs,DNAPK,DNPK1,DOXNPH,HYRC1,XRCC7,dxnph,p460
NCBI：19090#16186
MGI：104779#96551

销售状态：IF(正常销售)
保存方式： 活体,冷冻
品系背景：[N000235] NOD/ShiLtJGpt
微生物等级： SPF级

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品系策略： T001475.NCG strain info.pdf T001475.NCG 品系资料.pdf
研究领域：人源化模型
领域描述：1.人源免疫重建小鼠模型，如BLT人源化小鼠.PBMC人源化小鼠及CD34+人源化小鼠;2.人源肿瘤细胞.肿瘤组织移植(CDX，PDX);3.药效评价(小分子.大分子.联合用药);4.人类癌症模型;5.干细胞研究。

发表文献：

Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment https://doi.org/10.7150/thno.79367

Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling https://doi.org/10.1002/advs.202100914

Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML https://doi.org/10.1016/j.cmet.2022.04.004

Biomimetic Nanoerythrosome‐Coated Aptamer‐DNA Tetrahedron/Maytansine Conjugates: pH‐Responsive and Targeted Cytotoxicity for HER2‐positive Breast Cancer https://doi.org/10.1002/adma.202109609

Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment https://doi.org/10.1158/2159-8290.CD-21-1022

Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates https://doi.org/10.1038/s41421-021-00291-0

ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3 https://www.thno.org/v11p0841.htm

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1 https://doi.org/10.1002/ctm2.449

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling https://doi.org/10.1038/s41422-021-00528-3

Creatine promotes cancer metastasis through activation of Smad2/3 https://doi.org/10.1016/j.cmet.2021.03.009

Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cells https://doi.org/10.1158/1078-0432.CCR-21-0452

AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia https://doi.org/10.1038/s41408-021-00508-1

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors https://doi.org/10.1126/scitranslmed.abb5191

Development of an antibody-like T-cell engager based on VH-VL heterodimer formation and its application in cancer therapy https://doi.org/10.1016/j.biomaterials.2021.120760

The Rational Development of CD5-targeting Biepitopic Chimeric Antigen Receptors with Fully Human Heavy-chain-only Antigen Recognition Domains https://doi.org/10.1016/j.ymthe.2021.07.001

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression https://doi.org/10.1016/j.molcel.2021.07.003

Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors http://www.thno.org/v10p7622.htm

ARID1A hypermethylation disrupts transcriptional homeostasis to promote squamous cell carcinoma progression https://doi.org/10.1158/0008-5472

ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness https://doi.org/10.1038/s41418-019-0475-6

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy https://www.science.org/doi/10.1126/scitranslmed.aaz6667

Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging https://doi.org/10.7150/thno.36545

Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study http://doi.org/10.1038/s41422-022-00721-y

OXTR(High) stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling http://doi.org/10.1038/s41467-022-32787-y

Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL http://doi.org/10.1038/s41586-022-05140-y

Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer http://doi.org/10.1016/j.ccell.2022.08.010

Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma http://doi.org/10.1186/s13045-022-01359-4

Identification of novel HLA-A*11:01-restricted HPV16 E6/E7 epitopes and T-cell receptors for HPV-related cancer immunotherapy http://doi.org/10.1136/jitc-2022-004790

Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance https://doi.org/10.1016/j.jare.2022.11.006

Hook&Loop multivalent interactions based on disk-shaped nanoparticles strengthen active targeting https://doi.org/10.1016/j.jconrel.2023.01.022

Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy https://doi.org/10.1136/jitc-2022-005986

BPA‐Containing Polydopamine Nanoparticles for Boron Neutron Capture Therapy in a U87 Glioma Orthotopic Model https://doi.org/10.1002/adfm.202214145

Anti-BCMA surface engineered biomimetic photothermal nanomissile enhances multiple myeloma cell apoptosis and overcomes the disturbance of NF-kappaB signaling in vivo https://doi.org/10.1016/j.biomaterials.2023.122096

EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1 https://doi.org/10.1038/s41467-023-37954-3

Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche https://doi.org/10.3389/fimmu.2023.1157027

Supramolecular nanofibers co-loaded with dabrafenib and doxorubicin for targeted and synergistic therapy of differentiated thyroid carcinoma https://doi.org/10.7150/thno.82140

PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance https://doi.org/10.1126/sciadv.ade4186

Impaired histone inheritance promotes tumor progression https://doi.org/10.1038/s41467-023-39185-y

NOTCH4(DeltaL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1 https://doi.org/10.1038/s41467-023-38833-7

Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/beta-catenin positive feedback loop https://doi.org/10.1016/j.jare.2023.05.012

GAS6-based CAR-T cells exhibit potent antitumor activity against pancreatic cancer https://doi.org/10.1186/s13045-023-01467-9

Lenvatinib improves anti-PD-1 therapeutic efficacy by promoting vascular normalization via the NRP-1-PDGFRbeta complex in hepatocellular carcinoma https://doi.org/10.3389/fimmu.2023.1212577

Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment https://doi.org/10.1016/j.omto.2023.07.007

Preconditioning of radiotherapy enhances efficacy of B7-H3-CAR-T in treating solid tumor models https://doi.org/10.1016/j.lfs.2023.122024

Targeted delivery of a PD-1-blocking scFv by CD133-specific CAR-T cells using nonviral Sleeping Beauty transposition shows enhanced antitumour efficacy for advanced hepatocellular carcinoma https://doi.org/10.1186/s12916-023-03016-0

Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma https://doi.org/10.1016/j.isci.2023.107369

Treating solid tumors with TCR-based chimeric antigen receptor targeting extra domain B-containing fibronectin https://doi.org/10.1136/jitc-2023-007199

WDR54 exerts oncogenic roles in T-cell acute lymphoblastic leukemia https://doi.org/10.1111/cas.15872

Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity https://doi.org/10.1038/s41467-023-41101-3

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells https://doi.org/10.1002/1878-0261.13521

The application of HER2 and CD47 CAR-macrophage in ovarian cancer https://doi.org/10.1186/s12967-023-04479-8

A drug-delivery depot for epigenetic modulation and enhanced cancer immunotherapy https://doi.org/10.1016/j.biopha.2023.115687

A human mucosal melanoma organoid platform for modeling tumor heterogeneity and exploring immunotherapy combination options https://doi.org/10.1126/sciadv.adg668

Intratumoral CD103(+) CD8(+) T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma https://doi.org/10.1002/cac2.12480

Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression https://doi.org/10.1016/j.phrs.2023.106942

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer https://doi.org/10.1038/s41467-023-42332-0

Enhancement of the viability of T cells electroporated with DNA via osmotic dampening of the DNA-sensing cGAS-STING pathway https://doi.org/10.1038/s41551-023-01073-7

Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity https://doi.org/10.1016/j.celrep.2023.113211

Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models https://doi.org/10.1016/j.tranon.2023.101803

GARP-mediated active TGF-beta1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT https://doi.org/10.1182/blood.2022015474

Long noncoding RNA NONHSAT160169.1 promotes resistance via hsa-let-7c-3p/SOX2 axis in gastric cancer https://doi.org/10.1038/s41598-023-47961-5

Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51 https://doi.org/10.1038/s41467-023-42850-x

Tumor-infiltrating platelets promote the growth of lung adenocarcinoma https://doi.org/10.1016/j.tranon.2023.101813

Carboxypeptidase A4 negatively regulates HGS-ETR1/2-induced pyroptosis by forming a positive feedback loop with the AKT signalling pathway https://doi.org/10.1038/s41419-023-06327-5

Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application https://doi.org/10.1016/j.xcrm.2023.101277

Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma https://doi.org/10.1016/j.cmet.2023.11.019

Hepatitis B Virus-Encoded MicroRNA (HBV-miR-3) Inhibits FIH-1 Expression to Promote Tumor Angiogenesis in HBV-Related Hepatocellular Carcinoma https://doi.org/10.2147/JHC.S436926

A Near-Infrared-II Fluorescent Nanocatalyst for Enhanced CAR T Cell Therapy against Solid Tumor by Immune Reprogramming https://doi.org/10.1021/acsnano.3c02592

Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity https://doi.org/10.1002/iid3.1143

IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects https://doi.org/10.1016/j.isci.2023.108597

FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2alpha blockade by facilitating LDHA phosphorylation https://doi.org/10.1038/s41419-024-06450-x

Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting https://doi.org/10.1016/j.eng.2024.01.001

Cell-Surface GRP78-Targeted Chimeric Antigen Receptor T Cells Eliminate Lung Cancer Tumor Xenografts https://doi.org/10.3390/ijms25010564

An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL) https://doi.org/10.3390/biom14010106

Effects of methionine deficiency on B7H3-DAP12-CAR-T cells in the treatment of lung squamous cell carcinoma https://doi.org/10.1038/s41419-023-06376-w

Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis https://doi.org/10.1186/s13075-024-03271-3

RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9 https://doi.org/10.1186/s13059-023-03149-8

A trispecific antibody induces potent tumor-directed T-cell activation and antitumor activity by CD3/CD28 co-engagement https://doi.org/10.2217/imt-2023-0256

MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma https://doi.org/10.1038/s41419-024-06490-3

RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis https://doi.org/10.1016/j.celrep.2024.113786

High-fat diet promotes prostate cancer metastasis via RPS27 https://doi.org/10.1186/s40170-024-00333-7

CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma https://doi.org/10.1038/s41417-022-00512-y

The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments https://doi.org/10.1186/s12943-024-01938-8

RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid https://doi.org/10.1186/s12935-024-03299-0

Inhibition of SFTSV replication in humanized mice by a subcutaneously administered anti-PD1 nanobody https://doi.org/10.1038/s44321-024-00026-0

Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer https://doi.org/10.1007/s00262-024-03667-9

Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial https://doi.org/10.1038/s41467-024-47801-8

Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology https://doi.org/10.1186/s12967-024-05159-x

DR30318, a novel tri-specific T cell engager for Claudin 18.2 positive cancers immunotherapy https://doi.org/10.1007/s00262-024-03673-x

GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer https://doi.org/10.1186/s12915-024-01881-6

ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/beta-catenin/PD-L1 axis https://doi.org/10.1016/j.isci.2024.109533

m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia https://doi.org/10.1002/ctm2.1628

PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer https://doi.org/10.7150/ijbs.82361

PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion https://doi.org/10.1136/jitc-2023-008429

Self-Assembled Multivalent Aptamer Drug Conjugates: Enhanced Targeting and Cytotoxicity for HER2-Positive Gastric Cancer https://doi.org/10.1021/acsami.3c07344

STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells https://doi.org/10.1038/s41419-024-06638-1

Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1 https://doi.org/10.1016/j.gendis.2024.101330

CXCL10 and IL15 co-expressing chimeric antigen receptor T cells enhance anti-tumor effects in gastric cancer by increasing cytotoxic effector cell accumulation and survival https://doi.org/10.1080/2162402X.2024.2358590

Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes https://doi.org/10.1016/j.biopha.2024.116727

Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2 https://doi.org/10.1021/acs.jmedchem.4c00027

Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps" https://doi.org/10.1016/j.phrs.2024.107221

NCX1/Ca(2+) promotes autophagy and decreases bortezomib activity in multiple myeloma through non-canonical NFkappaB signaling pathway https://doi.org/10.1186/s12964-024-01628-4

Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells https://doi.org/10.1038/s41467-024-48607-4

Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN https://doi.org/10.1186/s12951-024-02505-5

Zebularine potentiates anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through cGAS-STING pathway https://doi.org/10.1038/s42003-024-06271-w

An herbal formula Shenlian decoction upregulates M1/M2 macrophage proportion in hepatocellular carcinoma by suppressing complement cascade https://doi.org/10.1016/j.biopha.2024.116943

EBV promotes TCR-T-cell therapy resistance by inducing CD163+M2 macrophage polarization and MMP9 secretion https://doi.org/10.1136/jitc-2023-008375

Liensinine diperchlorate and artemisitene synergistically attenuate breast cancer progression through suppressing PI3K-AKT signaling and their efficiency in breast cancer patient-derived organoids https://doi.org/10.1016/j.biopha.2024.116871

Preclinical evaluation of cyclophosphamide and fludarabine combined with CD19 CAR-T in the treatment of B-cell hematologic malignancies in vivo https://doi.org/10.32604/or.2024.049792

A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against ban https://doi.org/10.1128/jvi.00769-24

A distinct subset of urothelial cells with enhanced EMT features promotes chemotherapy resistance and cancer recurrence by increasing COL4A1-ITGB1 mediated angiogenesis https://doi.org/10.1016/j.drup.2024.101116

A general pHLA-CD80 scaffold fusion protein to promote efficient antigen-specific T cell-based immunotherapy https://doi.org/10.1016/j.omton.2024.200827

Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variants https://doi.org/10.1016/j.isci.2024.110366

N(6)-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor https://doi.org/10.1186/s13046-024-03113-9

Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin https://doi.org/10.1136/jitc-2024-008888

Pancreatic STAT5 activation promotes Kras(G12D)-induced and inflammation-induced acinar-to-ductal metaplasia and pancreatic cancer https://doi.org/10.1136/gutjnl-2024-332225

RSL3 enhances ROS-mediated cell apoptosis of myelodysplastic syndrome cells through MYB/Bcl-2 signaling pathway https://doi.org/10.1038/s41419-024-06866-5

ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8(+) T cells https://doi.org/10.1038/s41467-024-50077-7

An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy https://doi.org/10.1038/s43018-024-00760-x

PIM1/NF-kappaB/CCL2 blockade enhances anti-PD-1 therapy response by modulating macrophage infiltration and polarization in tumor microenvironment of NSCLC https://doi.org/10.1038/s41388-024-03100-6

Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE(2) production https://doi.org/10.1016/j.celrep.2024.114469

Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00448-5

COLEC10 inhibits the stemness of hepatocellular carcinoma by suppressing the activity of beta-catenin signaling https://doi.org/10.1007/s13402-024-00972-4

LIM domain only 7: a novel driver of immune evasion through regulatory T cell differentiation and chemotaxis in pancreatic ductal adenocarcinoma https://doi.org/10.1038/s41418-024-01358-7

Concomitant targeting of FLT3 and SPHK1 exerts synergistic cytotoxicity in FLT3-ITD(+) acute myeloid leukemia by inhibiting beta-catenin activity via the PP2A-GSK3beta axis https://doi.org/10.1186/s12964-024-01774-9

ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/beta-catenin activation https://doi.org/10.1093/nar/gkae707

Mito-LND and (E)-Akt inhibitor-IV: novel compounds inducing endoplasmic reticulum stress and ROS accumulation against hepatocellular carcinoma https://doi.org/10.1186/s12967-024-05545-5

PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells https://doi.org/10.1096/fj.202400687R

Development of a Novel Peptide-Based PET Tracer [(68)Ga]Ga-DOTA-BP1 for BCMA Detection in Multiple Myeloma https://doi.org/10.1021/acs.jmedchem.4c00759

Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance https://doi.org/10.1016/j.jare.2024.08.023

Reshaping tumor microenvironment by regulating local cytokines expression with a portable smart blue-light controlled device https://doi.org/10.1038/s42003-024-06566-y

CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression https://doi.org/10.3389/fphar.2024.1430891

PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability https://doi.org/10.1016/j.apsb.2024.08.003

A novel bispecific T-cell engager using the ligand-target csGRP78 against acute myeloid leukemia https://doi.org/10.1007/s00018-024-05410-0

Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancer https://doi.org/10.1016/j.xcrm.2024.101627

Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing. https://doi.org/10.1093/humrep/deae199 Human

ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells https://doi.org/10.1038/s43018-024-00821-1

Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1/YAP-mediated mechanosensing https://doi.org/10.1016/j.mtbio.2024.101245

BTN3A1 expressed in cervical cancer cells promotes Vγ9Vδ2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling https://doi.org/10.1186/s12964-024-01834-0

NL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia https://doi.org/10.1186/s12967-024-05647-0

The 8‐oxoguanine DNA glycosylase‐synaptotagmin 7 pathway increases extracellular vesicle release and promotes tumour metastasis during oxidative stress https://doi.org/10.1002/jev2.12505

Human intermediate prostate cancer stem cells contribute to the initiation and development of prostate adenocarcinoma https://doi.org/10.1186/s13287-024-03917-8

Single-cell sequencing analysis of multiple myeloma heterogeneity and identification of new theranostic targets https://doi.org/10.1038/s41419-024-07027-4

A highly selective PI3Kδ inhibitor BGB-10188 shows superior preclinical anti-tumor activities and decreased on-target side effects on colon https://doi.org/10.1016/j.neo.2024.101053

EphA2 specific chimeric antigen receptor engineered T cells for the treatment of prostate cancer https://doi.org/10.1016/j.tranon.2024.102111

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models https://doi.org/10.1186/s12967-024-05568-y

YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer https://doi.org/10.1158/0008-5472.CAN-24-0932/3484967/can-24-0932.pdf

ACSL6-activated IL-18R1–NF-κB promotes IL-18–mediated tumor immune evasion and tumor progression. https://doi.org/10.1126/sciadv.adp071

Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells https://doi.org/10.3389/fimmu.2024.1433679