CDX模型(Cell line-derived xenograft model)是将人源的肿瘤细胞移植到小鼠的皮下,用于药效学评价或者肿瘤相关科学研究,是目前抗肿瘤药物临床前药效学评价最常用的体内模型之一。
集萃药康拥有包括胰腺癌、乳腺癌、结肠癌、肺癌、淋巴癌在内的多种CDX模型。可满足多种药效实验需求。
癌种 | tumor type | name of cell lines |
膀胱癌 | Bladder | UM-UC-3,HT1376,RT112/84,RT4 |
恶性胶质瘤 | Brain | U251,U87 MG |
乳腺癌 | Breast | BT-474,HCC1937,HCC1954,HCC1569,JIMT-1,MCF7,MDA-MB-231,MDA-MB-453,MDA-MB-468,HCC70,T47D,HCC1806,ZR-75-1,DU4475 |
结直肠癌 | Colorectal | Colo205,HCT116,HT-29,HT55,LS174T,RKO,LS1034,SW48,Lovo,SW620,T84,DLD-1,HCT15,COLO-320 |
十二指肠癌 | Duodenal | HuTu80 |
非小细胞肺癌 | NSCLC | A549,Calu-3,HCC-827,NCI-H1703,NCI-H1975,NCI-H2122,NCI-H226,NCI-H292,NCI-H358,NCI-H460,NCI-H727,NCI-H1650,Calu-6,PC-9,NCI-H520,NCI-H2228,SK-MES-1,NCI-H838,NCI-H1568,NCI-H441 |
小细胞肺癌 | SCLC | NCI-H69, NCI-H446, NCI-H526, NCI-H82, SHP-77,NCI-H209 |
黑色素瘤 | Melanoma | A375,SK-MEL-28,SK-MEL-5 |
多重骨髓癌 | Multiple Myeloma | RPMI8226,NCI-H929,MM.1R,MOLP-8 |
卵巢癌 | Ovary | OVCAR-3,SK-OV-3,PA-1,ES-2 |
胰腺癌 | Pancreas | AsPC-1,BxPC-3,CAPAN-1,PANC-1,MIA PaCa-2,SW1990,HPAFII,CAPAN-2,HPAC |
前列腺癌 | Prostate | LNCaP,PC-3,DU 145,22RV-1 |
肾癌 | Renal | ACHN,786-0 |
皮肤癌 | Skin Cancer | A431,A2058 |
肉瘤(纤维肉瘤,骨肉瘤 | Sarcoma | SJSA-1,SW1353,HT1080 |
肝癌 | Liver | HepG2,Huh7,SK-Hep-1 |
胃癌 | Gastric | Hs746T,MKN45,NCI-N87,NUGC4,NUGC4(NUGC4-CLaudin18.2) |
头颈部癌 | Head and Neck Cancer | A253,FaDu,Cal27 |
子宫内膜癌 | EndometriaL carcinoma | HEC-1-A |
白血病 | Leukemia | HL-60,Jurkat,K562,MOLT-4,MV-4-11,Nalm-6,SUP-B15,THP-1,MOLM13,OCIAML3,U937 |
淋巴瘤 | Lymphoma | Jeko-1,MM.1S,Raji,Ramos,SU-DHL-10 |