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List of Gene edited MC38 derivatives

Target

Cell line

Tumor Type

Availability

PDL1

MC38-hPDL1(Tg)-mPDL1(KO)

Colorectal cancer 

Available

mCLDN18.2

MC38-hPDL1(Tg)-mPDL1(KO)-mCLDN18.2(Tg)

Colorectal cancer 

Available

CD47

MC38-hCD47 (Tg)-mCD47(KO)

Colorectal cancer 

Available

PDL1/CD47

MC38-hPDL1(Tg)-mPDL1(KO) -hCD47(Tg)-mCD47(KO) 

Colorectal cancer 

Available

CD73

MC38-hCD73 (Tg)-mCD73(KO)

Colorectal cancer 

Available

PDL1/CD73

MC38-hPDL1(Tg)-mPDL1(KO) hCD73(Tg)-mCD73(KO) 

Colorectal cancer 

Available

Nectin4

MC38-hNectin4 (Tg)-mNectin4(KO)

Colorectal cancer 

Available

hPDL1/hB7H3

MC38-hPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)

Colorectal cancer 

Available

siglec15

MC38-hsiglec15 (Tg)-msiglec15(KO)

Colorectal cancer 

Available

BCMA

MC38-mBCMA(Tg) cell line Generation and Validation 

Colorectal cancer 

Available