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C57BL/6JGpt-Rag1em1Cd3259/Gpt
B6-Rag1-KO|Strain
NO.T004753
Knockout (KO)
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C57BL/6JGpt-Rag1em1Cd3259/Gpt
B6-Rag1-KO|Strain
NO.T004753
Knockout (KO)
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- 周龄： --
- 基因型： --
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C57BL/6JGpt-Rag1em1Cd3259/Gpt
B6-Rag1-KO|Strain
NO.T004753
Knockout (KO)
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周 龄
基因型
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- 基本信息
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000013] C57BL/6JGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T004753.B6-Rag1-KO strain info.pdf T004753.B6-Rag1-KO 品系资料.pdf
- 研究领域：人源化模型
- 领域描述：1.免疫学研究;2.感染.炎症等研究;3.肿瘤移植;4.人源化BTLA抑制剂的药效评价。
- 发表文献：
Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors https://doi.org/10.1186/s13045-021-01112-3 Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation https://doi.org/10.1016/j.phrs.2021.105459 Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ https://doi.org/10.3389/fcell.2021.637424 Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy https://doi.org/10.15252/emmm.202114059 Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity http://dx.doi.org/10.1136/jitc-2020-002137 Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-beta signaling in regulatory T cells https://doi.org/10.1016/j.celrep.2022.110986 The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness https://doi.org/10.1038/s41467-022-30707-8 The immunometabolite S-2-hydroxyglutarate exacerbates perioperative ischemic brain injury and cognitive dysfunction by enhancing CD8+ T lymphocyte-mediated neurotoxicity https://doi.org/10.1186/s12974-022-02537-4 Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression https://doi.org/10.1038/s41467-022-31417-x Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activation https://doi.org/10.1080/2162402X.2022.2093054 Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity https://doi.org/10.1038/s41467-022-34253-1 Nsun2 coupling with RoRgammat shapes the fate of Th17 cells and promotes colitis https://doi.org/10.1038/s41467-023-36595-w A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis https://doi.org/10.1038/s41422-023-00790-7 Intrinsic RIG-I restrains STAT5 activation to modulate antitumor activity of CD8+ T cells https://doi.org/10.1172/JCI160790 Establishment of cell culture model and humanized mouse model of chronic hepatitis B virus infection https://doi.org/10.1128/spectrum.02745-23 Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8(+) T-cell exhaustion https://doi.org/10.1038/s41467-023-43988-4 Dietary fructose-mediated adipocyte metabolism drives antitumor CD8(+) T cell responses https://doi.org/10.1016/j.cmet.2023.09.011 RORalpha is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis https://doi.org/10.1016/j.celrep.2024.113786 Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice https://doi.org/10.1016/j.celrep.2024.113817 Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer https://doi.org/10.1016/j.cell.2024.02.022 A single-chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice https://doi.org/10.1111/jcmm.18291 A pathological joint-liver axis mediated by matrikine-activated CD4(+) T cells https://doi.org/10.1038/s41392-024-01819-y The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells https://doi.org/10.1016/j.celrep.2024.114222 Reconstituted CD74(+) NK cells trigger chronic graft versus host disease after allogeneic bone marrow transplantation https://doi.org/10.1016/j.jaut.2024.103274 VISTA Deficiency Exacerbates the Development of Pulmonary Fibrosis by Promoting Th17 Differentiation https://doi.org/10.2147/JIR.S458651 TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma https://doi.org/10.1038/s41467-024-52252-2 Unraveling the spatial organization and development of human thymocytes through integration of spatial transcriptomics and single-cell multi-omics profiling https://doi.org/10.1038/s41467-024-51767-y PAC1 constrains type II inflammation through promotion of CGRP signaling in ILC2s https://doi.org/10.1172/JCI180109 Crystalline silica-induced recruitment and immuno-imbalance of CD4(+) tissue resident memory T cells promote silicosis progression https://doi.org/10.1038/s42003-024-06662-z
*使用本品系发表的文献需注明：B6-Rag1-KO mice（Strain NO.T004753）were purchased from GemPharmatech (Nanjing, China).
