集萃药康|BALB/c-hPD1/hPDL1

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C57
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糖尿病
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BALB/cJGpt-Pdcd1^{em1Cin(hPDCD1)}Cd274^tm1(hCD274)/Gpt

BALB/c-hPD1/hPDL1|Strain NO.T004025

Knockin(KI)

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BALB/cJGpt-Pdcd1^{em1Cin(hPDCD1)}Cd274^tm1(hCD274)/Gpt

BALB/c-hPD1/hPDL1|Strain NO.T004025

Knockin(KI)

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BALB/cJGpt-Pdcd1^{em1Cin(hPDCD1)}Cd274^tm1(hCD274)/Gpt

BALB/c-hPD1/hPDL1|Strain NO.T004025

Knockin(KI)

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BALB/cJGpt-Pdcd1^{em1Cin(hPDCD1)}Cd274^tm1(hCD274)/Gpt

BALB/c-hPD1/hPDL1|Strain NO.T004025

Knockin(KI)

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基本信息

基因官方名：Pdcd1,PDCD1,Cd274,CD274
基因全名：programmed cell death 1,CD274 antigen,CD274 molecule
基因别名：PD-1,Pdc1,Ly101,PD1,CD279,SLEB2,hPD-1,hPD-l,hSLE1,B7h1,Pdl1,Pdcd1l1,Pdcd1lg
NCBI：18566#5133#60533#29126
MGI：104879

销售状态：IF(正常销售)
保存方式： 活体,冷冻
品系背景：[N000020] BALB/cJGpt
微生物等级： SPF级

品系策略： 登录后查看品系策略，点我登录
品系策略： T004025. BALBc-hPD1-hPDL1 strain info.pdf T004025. BALBc-hPD1-hPDL1 品系资料.pdf
研究领域：人源化模型,基因人源化模型
领域描述：1.筛选人源PDL1抑制剂或人源PD1抑制剂;2.人源PDL1抑制剂及人源PD1抑制剂联合用药药效及安全性评价;3.抗肿瘤研究;4.自身免疫病研究。

发表文献：

PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way http://doi.org/10.1136/jitc-2022-004590

*使用本品系发表的文献需注明：BALB/c-hPD1/hPDL1 mice（Strain NO.T004025）were purchased from GemPharmatech (Nanjing, China).

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