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C57BL/6JGpt-Ldlrem1Cd82/Gpt
Ldlr-KO|Strain
NO.T001464
Knockout (KO)
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C57BL/6JGpt-Ldlrem1Cd82/Gpt
Ldlr-KO|Strain
NO.T001464
Knockout (KO)
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- 周龄： --
- 基因型： --
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C57BL/6JGpt-Ldlrem1Cd82/Gpt
Ldlr-KO|Strain
NO.T001464
Knockout (KO)
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周 龄
基因型
*以发货时库存基因型为准
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- 基本信息
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000013] C57BL/6JGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T001464.Ldlr-KO strain info.pdf
- 研究领域：疾病与药物评价模型
- 领域描述：1.动脉粥样硬化(AS)及心血管疾病的病理生理研究；2.血管扩张类药物的筛选；3.AS诊断试剂盒开发；4.高胆固醇血症相关。
- 发表文献：
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice https://doi.org/10.1039/D0FO03475D Aberrant oligodendroglial LDL receptor orchestrates demyelination in chronic cerebral ischemia https://doi.org/10.1172/JCI128114 circGNAQ, a Circular RNA Enriched in Vascular Endothelium, Inhibits Endothelial Cell Senescence and Atherosclerosis Progression https://doi.org/10.1016/j.omtn.2021.07.020 Exendin-4 attenuates atherosclerosis progression via controlling hematopoietic stem/progenitor cell proliferation https://doi.org/10.1093/jmcb/mjad014 Tanshinone IIA alleviates atherosclerosis in LDLR(-/-) mice by regulating efferocytosis of macrophages https://doi.org/10.3389/fphar.2023.1233709 Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways https://doi.org/10.1093/eurheartj/ehad796 LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus https://doi.org/10.1038/s41422-023-00917-w Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion https://doi.org/10.1038/s41586-022-05006-3 A gut-derived hormone regulates cholesterol metabolism https://doi.org/10.1016/j.cell.2024.02.024 Apolipoprotein O modulates cholesterol metabolism via NRF2/CYB5R3 independent of LDL receptor https://doi.org/10.1038/s41419-024-06778-4 siRNA nanoparticle targeting Usp20 lowers lipid levels and ameliorates metabolic syndrome in mice https://doi.org/10.1016/j.jlr.2024.100626
*使用本品系发表的文献需注明：Ldlr-KO mice（Strain NO.T001464）were purchased from GemPharmatech (Nanjing, China).
