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C57BL/6JGpt-Lepem1Cd25/Gpt
B6-ob|Strain
NO.T001461
Knockout (KO)
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C57BL/6JGpt-Lepem1Cd25/Gpt
B6-ob|Strain
NO.T001461
Knockout (KO)
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- 基因型： --
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C57BL/6JGpt-Lepem1Cd25/Gpt
B6-ob|Strain
NO.T001461
Knockout (KO)
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周 龄
基因型
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- 基本信息
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000013] C57BL/6JGpt
- 微生物等级： SPF级
- 研究领域：疾病与药物评价模型,代谢模型,肥胖模型
- 领域描述：1、肥胖症研究及肥胖治疗药物非临床评价;2、研究“瘦素”的信号通路;3、生殖生理研究。
- 发表文献：
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity https://doi.org/10.1016/j.cmet.2021.02.007 Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo https://doi.org/10.1002/advs.202000818 Hypoglycemic effects of polysaccharides from Gomphidiaceae rutilus fruiting bodies and their mechanisms https://doi.org/10.1039/C9FO02283J Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model https://doi.org/10.1016/j.lfs.2020.118966 Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging https://doi.org/10.1021/acs.analchem.1c00498 Immunotherapy against angiotensin II receptor ameliorated insulin resistance in a leptin receptor‐dependent manner https://doi.org/10.1096/fj.202000300R Dahuang Fuzi Baijiang decoction restricts progenitor to terminally exhausted T cell differentiation in colorectal cancer https://doi.org/10.1111/cas.15311 MicroRNA-21 promotes pancreatic beta cell function through modulating glucose uptake https://doi.org/10.1038/s41467-022-31317-0 Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer https://doi.org/10.1002/advs.202203357 Anti-aging mechanism of different age donor-matched adipose-derived stem cells https://doi.org/10.1186/s13287-023-03415-3 Brown adipose Vanin-1 is required for the maintenance of mitochondrial homeostasis and prevents diet-induced metabolic dysfunction https://doi.org/10.1016/j.molmet.2024.101884 Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor) https://doi.org/10.1038/s41392-023-01727-7 Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes https://doi.org/10.1016/j.heliyon.2024.e27618 Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate https://doi.org/10.1021/acsnanoscienceau.3c00035 Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption https://doi.org/10.1038/s42255-024-01072-1 USP13 ameliorates nonalcoholic fatty liver disease through inhibiting the activation of TAK1 https://doi.org/10.1186/s12967-024-05465-4
*使用本品系发表的文献需注明：B6-ob mice（Strain NO.T001461）were purchased from GemPharmatech (Nanjing, China).
