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C57BL/6JGpt-Apoeem1Cd82/Gpt
Apoe-KO|Strain
NO.T001458
Knockout (KO)
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C57BL/6JGpt-Apoeem1Cd82/Gpt
Apoe-KO|Strain
NO.T001458
Knockout (KO)
- 性别： --
- 周龄： --
- 基因型： --
- 选择数量：
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C57BL/6JGpt-Apoeem1Cd82/Gpt
Apoe-KO|Strain
NO.T001458
Knockout (KO)
性 别
周 龄
基因型
*以发货时库存基因型为准
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- 基本信息
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000013] C57BL/6JGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： T001458.Apoe-KO strain info.pdf T001458.Apoe-KO 品系资料.pdf
- 研究领域：疾病与药物评价模型
- 领域描述：1.心血管疾病研究：动脉粥样硬化.高胆固醇血症.高血脂症2.脂代谢研究3.神经生物学研究：阿尔兹海默症.行为及学习障碍.神经退行性疾病。
- 发表文献：
Nicotine modulates CTSS (cathepsin S) synthesis and secretion through regulating the autophagy-lysosomal machinery in atherosclerosis https://doi.org/10.1161/ATVBAHA.120.314053 LncRNA NORAD promotes vascular endothelial cell injury and atherosclerosis through suppressing VEGF gene transcription via enhancing H3K9 deacetylation by recruiting HDAC6 https://doi.org/10.3389/fcell.2021.701628 Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway https://doi.org/10.3390/antiox10060916 Targeting macrophage liver X receptors by hydrogel‐encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis https://doi.org/10.1111/bph.15387 BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis https://doi.org/10.1016/j.redox.2021.101979 BTK Promotes Atherosclerosis by Regulating Oxidative Stress, Mitochondrial Injury, and ER Stress of Macrophages https://doi.org/10.1155/2021/9972413 ZBTB20 Positively Regulates Oxidative Stress, Mitochondrial Fission, and Inflammatory Responses of ox-LDL-Induced Macrophages in Atherosclerosis https://doi.org/10.1155/2021/5590855 circDENND1B Participates in the Antiatherosclerotic Effect of IL-1β Monoclonal Antibody in Mouse by Promoting Cholesterol Efflux via miR-17-5p/Abca1 Axis https://doi.org/10.3389/fcell.2021.652032 ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway https://www.thno.org/v11p1129.htm Activated invariant natural killer T cells infiltrate aortic tissue as key participants in abdominal aortic aneurysm pathology https://doi.org/10.1111/imm.13401 Qing-Xin-Jie-Yu Granule alleviates atherosclerosis by reshaping gut microbiota and metabolic homeostasis of ApoE-/- mice https://doi.org/10.1016/j.phymed.2022.154220 Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production https://doi.org/10.1016/j.cellsig.2022.110419 Dual-responsive targeted atherosclerosis therapy through a multi-effective nanoplatform with anti-inflammatory, lipid-regulating and autophagy https://doi.org/10.1016/j.cej.2022.140067 JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis https://doi.org/10.1186/s13045-022-01381-6 Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect https://doi.org/10.1186/s12951-022-01720-2 Natural Cell Patches: Melanin Nanoparticles for MR Imaging‐Guided Antiatherosclerosis Therapy via Attenuating Macrophage Pyroptosis https://doi.org/10.1002/adfm.202212748 Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses https://doi.org/10.15252/emmm.202217198 Lipid-accumulated reactive astrocytes promote disease progression in epilepsy https://doi.org/10.1038/s41593-023-01288-6 Plaque Macrophage‐Targeting Nanosystems with Cooperative Co‐Regulation of ROS and TRAF6 for Stabilization of Atherosclerotic Plaques https://doi.org/10.1002/adfm.202301053 Multi-omics reveals aspirin eugenol ester alleviates neurological disease https://doi.org/10.1016/j.biopha.2023.115311 Rational Design of a Double-Locked Photoacoustic Probe for Precise In Vivo Imaging of Cathepsin B in Atherosclerotic Plaques https://doi.org/10.1021/jacs.3c04981 Sulfated glucuronomannan hexamer inhibits lipid accumulation and ameliorates atherosclerosis in apolipoprotein E-deficient mice https://doi.org/10.1016/j.jff.2023.105742 Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis https://doi.org/10.1126/sciadv.adh1037 An elastase-inhibiting, plaque-targeting and neutrophil-hitchhiking liposome against atherosclerosis https://doi.org/10.1016/j.actbio.2023.11.020 Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn https://doi.org/10.1186/s13062-023-00444-z Transcriptome analysis reveals therapeutic potential of NAMPT in protecting against abdominal aortic aneurysm in human and mouse https://doi.org/10.1016/j.bioactmat.2023.11.020 lncRNA JPX-Enriched Chromatin Microenvironment Mediates Vascular Smooth Muscle Cell Senescence and Promotes Atherosclerosis https://doi.org/10.1161/ATVBAHA.122.319250 S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype https://doi.org/10.3389/fcell.2023.1291170 Medium-Dose Formoterol Attenuated Abdominal Aortic Aneurysm Induced by EPO via beta2AR/cAMP/SIRT1 Pathway https://doi.org/10.1002/advs.202306232 Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway https://doi.org/10.1016/j.jtcme.2024.03.015 Key chromatin regulator-related genes associated with the risk of coronary artery disease regulate the expression of HCFC1, RNF8, TNP1 and SET https://doi.org/10.1016/j.heliyon.2024.e28685 Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE (-/-) mice https://doi.org/10.1016/j.bcp.2024.116170 FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque https://doi.org/10.2147/JIR.S447379 Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic plaque vulnerability via macrophage Dll4 signaling https://doi.org/10.1038/s41467-024-45582-8 ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT https://doi.org/10.1016/j.apsb.2024.03.008 LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis https://doi.org/10.1161/CIRCRESAHA.122.322360 Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy https://doi.org/10.1007/s10565-024-09873-6 Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation https://doi.org/10.1111/jcmm.18402 Glutamine Protects against Mouse Abdominal Aortic Aneurysm through Modulating VSMC Apoptosis and M1 Macrophage Activation https://doi.org/10.7150/ijms.96395 Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation https://doi.org/10.1016/j.celrep.2024.114180 Limosilactobacillus fermentum TY-S11 ameliorates hypercholesterolemia via promoting cholesterol excretion and regulating gut microbiota in high-cholesterol diet-fed apolipoprotein E-deficient mice https://doi.org/10.1016/j.heliyon.2024.e32059 Reparative effects after low-dose radiation exposure: Inhibition of atherosclerosis by reducing NETs release https://doi.org/10.1016/j.scitotenv.2024.174540 Radiation-Induced Endothelial Ferroptosis Accelerates Atherosclerosis via the DDHD2-Mediated Nrf2/GPX4 Pathway https://doi.org/10.3390/biom14070879 Increased Expression of Mevalonate Pathway-Related Enzymes in Angiotensin II-Induced Abdominal Aortic Aneurysms https://doi.org/10.1536/ihj.23-623 The metabolite 2-Methylbutyrylcarnitine does not Promote Atherosclerosis in Apolipoprotein E-Deficient Mice https://doi.org/10.15212/bioi-2024-0049 Mechanism of Bile Acid in Regulating Platelet Function and Thrombotic Diseases https://doi.org/10.1002/advs.202401683 Trimethylamine N-oxide promotes PERK-mediated endothelial-mesenchymal transition and apoptosis thereby aggravates atherosclerosis https://doi.org/10.1016/j.intimp.2024.113209 MiRNA-132/212 encapsulated by adipose tissue-derived exosomes worsen atherosclerosis progression https://doi.org/10.1186/s12933-024-02404-x SGK1 contributes to ferroptosis in coronary heart disease through the NEDD4L/NF-κB pathway https://doi.org/10.1016/j.yjmcc.2024.09.001 Palmatine protects against atherosclerosis by gut microbiota and phenylalanine metabolism https://doi.org/10.1016/j.phrs.2024.107413 Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1 https://doi.org/10.1186/s12929-024-01076-9 SIRT1 mediates the inflammatory response of macrophages and regulates the TIMP3/ADAM17 pathway in atherosclerosis https://doi.org/10.1016/j.yexcr.2024.114253
*使用本品系发表的文献需注明：Apoe-KO mice（Strain NO.T001458）were purchased from GemPharmatech (Nanjing, China).
