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BALB/cNj-Foxn1nu/Gpt
BALB/c-Nude|Strain
NO.D000521
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BALB/c-Nude|Strain
NO.D000521
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BALB/cNj-Foxn1nu/Gpt
BALB/c-Nude|Strain
NO.D000521
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- 品系说明：裸鼠，成瘤情况可参考网页信息 https://cn.gempharmatech.com/service/cdx.html
- 销售状态：IF(正常销售)
- 保存方式： 活体,冷冻
- 品系背景：[N000020] BALB/cJGpt
- 微生物等级： SPF级
- 品系策略： 登录后查看品系策略，点我登录
- 品系策略： D000521.BALB_c-Nude strain info.pdf D000521.BALB_c-Nude 品系资料.pdf
- 领域描述：1.皮肤病学研究：皮毛结构缺陷;2.内分泌缺陷研究：肾上腺皮质缺陷，皮肤缺陷，甲状腺缺陷;3.免疫和炎症研究：免疫缺陷(T细胞缺乏);4.内部/器官研究：胸腺缺陷;5.研究工具：癌症研究(异种移植/移植主体)，免疫和炎症研究(T细胞缺乏)。
- 发表文献：
A dynamic DNA tetrahedron framework for active targeting https://doi.org/10.1038/s41596-022-00791-7 Highly efficient fabrication of functional hepatocyte spheroids by a magnetic system for the rescue of acute liver failure https://doi.org/10.1016/j.biomaterials.2023.122014 DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2 https://doi.org/10.1038/s41392-022-01096-7 Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-beta/SMAD3 pathway https://doi.org/10.1186/s13045-022-01331-2 Targeting FAPα-expressing hepatic stellate cells overcomes resistance to anti-angiogenics in colorectal cancer liver metastasis models https://doi.org/10.1172/JCI157399 Generation of a live attenuated influenza A vaccine by proteolysis targeting https://doi.org/10.1038/s41587-022-01381-4 Allosteric activation of the metabolic enzyme GPD1 inhibits bladder cancer growth via the lysoPC-PAFR-TRPV2 axis https://doi.org/ 10.1186/s13045-022-01312-5 Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis: therapeutic potential for endogenous pulp regeneration https://doi.org/10.1038/s41368-022-00188-y A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies https://doi.org/10.1016/j.molcel.2021.07.021 Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm https://doi.org/10.1002/advs.202100779 NIR‐Activated Multimodal Photothermal/Chemodynamic/Magnetic Resonance Imaging Nanoplatform for Anticancer Therapy by Fe (II) Ions Doped MXenes (Fe‐Ti3C2) https://doi.org/10.1002/smll.202101705 Polypeptide uploaded efficient nanophotosensitizers to overcome photodynamic resistance for enhanced anticancer therapy https://doi.org/10.1016/j.cej.2020.126344 Cell‐Released Magnetic Vesicles Capturing Metabolic Labeled Rare Circulating Tumor Cells Based on Bioorthogonal Chemistry https://doi.org/10.1002/smll.202007796 MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage https://doi.org/10.1016/j.ccell.2020.12.010 TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα https://doi.org/10.1038/s41418-020-00606-w Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells https://doi.org/10.1126/sciadv.abe3445 Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity https://doi.org/10.1038/s41392-021-00652-x Smart Acid‐Activatable Self‐Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy https://doi.org/10.1002/adfm.202003338 Heat stress activates YAP/TAZ to induce the heat shock transcriptome https://doi.org/10.1038/s41556-020-00602-9 Integrated omics of metastatic colorectal cancer https://doi.org/10.1016/j.ccell.2020.08.002 Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma https://doi.org/10.1038/s41422-020-00402-8 Clonal mutations activate the NF-κB pathway to promote recurrence of nasopharyngeal carcinoma https://cancerres.aacrjournals.org/content/79/23/5930.short In Vivo Bioorthogonal Labeling of Rare-Earth Doped Nanoparticles for Improved NIR-II Tumor Imaging by Extracellular Vesicle-Mediated Targeting http://doi.org/10.1007/s12274-022-5033-8 Rational Design of pH-Activated Upconversion Luminescent Nanoprobes for Bioimaging of Tumor Acidic Microenvironment and the Enhancement of Photothermal Therapy http://doi.org/10.1016/j.actbio.2022.08.078 FBW7-mediated ubiquitination and destruction of PD-1 protein primes sensitivity to anti-PD-1 immunotherapy in non-small cell lung cancer http://doi.org/10.1136/jitc-2022-005116 MAP7D2 reduces CD8(+) cytotoxic T lymphocyte infiltration through MYH9-HMGB1 axis in colorectal cancer http://doi.org/10.1016/j.ymthe.2022.09.001 The synergistic regulation of chondrogenesis by collagen-based hydrogels and cell co-culture http://doi.org/10.1016/j.actbio.2022.10.017 Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth http://doi.org/10.1016/j.biomaterials.2022.121823 TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma http://doi.org/10.1172/JCI157649 Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation http://doi.org/10.1136/jitc-2022-004874 ATF4-dependent fructolysis fuels growth of glioblastoma multiforme http://doi.org/10.1038/s41467-022-33859-9 Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system http://doi.org/10.1038/s41467-022-33788-7 Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment https://doi.org/10.1016/j.bioactmat.2022.10.025 Orthogonal excitations of lanthanide nanoparticle up/down conversion emissions via switching NIR lights for in-vivo theranostics https://doi.org/10.1016/j.biomaterials.2022.121873 A carbon monoxide releasing metal organic framework nanoplatform for synergistic treatment of triple-negative breast tumors https://doi.org/10.1186/s12951-022-01704-2 Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation https://doi.org/10.1038/s41467-022-35199-0 CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug https://doi.org/10.1186/s12943-022-01694-7 CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin https://doi.org/10.1186/s40824-022-00312-3 Efficiently targeted therapy of glioblastoma xenograft via multifunctional biomimetic nanodrugs https://doi.org/10.1186/s40824-022-00309-y The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling https://doi.org/10.1038/s41421-022-00478-z BGN/FAP/STAT3 positive feedback loop mediated mutual interaction between tumor cells and mesothelial cells contributes to peritoneal metastasis of gastric cancer https://doi.org/10.7150/ijbs.72218 A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers https://doi.org/10.1038/s41422-022-00726-7 Phosphomevalonate Kinase Controls beta-Catenin Signaling via the Metabolite 5-Diphosphomevalonate https://doi.org/10.1002/advs.202204909 Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations https://doi.org/10.1016/j.apsb.2023.03.007 Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes beta-catenin palmitoylation to drive colorectal cancer progression https://doi.org/10.1038/s41421-022-00515-x METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression https://doi.org/10.1002/cac2.12403 Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells https://doi.org/10.1016/j.ebiom.2023.104496 A radiohybrid theranostics ligand labeled with fluorine-18 and lutetium-177 for fibroblast activation protein-targeted imaging and radionuclide therapy https://doi.org/10.1007/s00259-023-06169-5 Modulating tumor-stromal crosstalk via a redox-responsive nanomedicine for combination tumor therapy https://doi.org/10.1016/j.jconrel.2023.03.015 LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia https://doi.org/10.1186/s13045-023-01429-1 Nano-magnetic aptamer sensor incorporating AND logic recognition-launched hybridization chain reaction for organ origin identification of circulating tumor cells https://doi.org/10.1016/j.nantod.2023.101817 CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway https://doi.org/10.1007/s10637-023-01360-9 EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1 https://doi.org/10.1038/s41467-023-37954-3 Stimuli-responsive heparin-drug conjugates co-assembled into stable nanomedicines for cancer therapy https://doi.org/10.1016/j.actbio.2023.04.016 The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma https://doi.org/10.1126/sciadv.adf0005 PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells https://doi.org/10.1016/j.jare.2023.04.015 Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy https://doi.org/10.1016/j.apsb.2023.05.026 SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool https://doi.org/10.1038/s41556-023-01138-4 SUMO specific peptidase 3 halts pancreatic ductal adenocarcinoma metastasis via deSUMOylating DKC1 https://doi.org/10.1038/s41418-023-01175-4 Synergism of FAK and ROS1 inhibitors in the treatment of CDH1-deficient cancers mediated by FAK-YAP signaling https://doi.org/10.7150/ijbs.81918 Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy https://doi.org/10.1126/sciadv.adh1736. B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma https://doi.org/10.1186/s13046-023-02711-3 Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer https://doi.org/10.1016/j.ebiom.2023.104650 NOTCH4(DeltaL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1 https://doi.org/10.1038/s41467-023-38833-7 Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC https://doi.org/10.1186/s13046-023-02734-w Chronic stress accelerates glioblastoma progression via DRD2/ERK/beta-catenin axis and Dopamine/ERK/TH positive feedback loop https://doi.org/10.1186/s13046-023-02728-8 Inhibition of DPAGT1 suppresses HER2 shedding and trastuzumab resistance in human breast cancer https://doi.org/10.1172/JCI164428 Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis https://doi.org/10.1016/j.isci.2023.107477 A biomimetic nanoreactor for combinational chemo/chemodynamic therapy of choriocarcinoma through synergistic apoptosis and ferroptosis strategy https://doi.org/10.1016/j.cej.2023.144690 CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression https://doi.org/10.1038/s41419-023-06088-1 FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer https://doi.org/10.1038/s41419-023-06027-0 FOXP1-GINS1 axis promotes DLBCL proliferation and directs doxorubicin resistance https://doi.org/10.7150/jca.85906 HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10408493/ Inetetamab, a novel anti-HER2 monoclonal antibody, exhibits potent synergistic anticancer effects with cisplatin by inducing pyroptosis in lung adenocarcinoma https://doi.org/10.7150/ijbs.82980 Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation https://doi.org/10.3892/etm.2023.12156 PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair https://doi.org/10.1016/j.jbc.2023.105032 A mitochondrial EglN1-AMPKalpha axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress https://doi.org/10.15252/embj.2023113743 A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer https://doi.org/10.3892/ol.2023.14040 CLASRP oncogene as a novel target for colorectal cancer https://doi.org/10.1007/s10142-023-01208-8 DAB2IP suppresses invadopodia formation through destabilizing ALK by interacting with USP10 in breast cancer https://doi.org/10.1016/j.isci.2023.107606 ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer https://doi.org/10.1002/cam4.6516 Epidermal growth factor receptor regulates lineage plasticity driving transformation to small cell lung cancer https://doi.org/10.1016/j.bbrc.2023.09.047 In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy https://doi.org/10.1038/s41419-023-06159-3 LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer https://doi.org/10.1186/s12967-023-04401-2 LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter https://doi.org/10.1186/s12885-023-11403-2 Long-read sequencing reveals the landscape of aberrant alternative splicing and novel therapeutic target in colorectal cancer https://doi.org/10.1186/s13073-023-01226-y Single-cell RNA reveals a tumorigenic microenvironment in the interface zone of human breast tumors https://doi.org/10.1186/s13058-023-01703-7 Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression https://doi.org/10.1371/journal.pone.0290264 Beauvericin suppresses the proliferation and pulmonary metastasis of osteosarcoma by selectively inhibiting TGFBR2 pathway https://doi.org/10.7150/ijbs.86214 Design, Synthesis, and Biological Evaluation of a Novel [(18)F]-Labeled Arginine Derivative for Tumor Imaging https://doi.org/10.3390/ph16101477 Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer https://doi.org/10.1038/s41388-023-02866-5 Ginsenoside Rh4 inhibits inflammation-related hepatocellular carcinoma progression by targeting HDAC4/IL-6/STAT3 signaling https://doi.org/10.1007/s00438-023-02070-w Heat shock protein B7 (HSPB7) inhibits lung adenocarcinoma progression by inhibiting glycolysis https://doi.org/10.3892/or.2023.8633 High-risk histological subtype-related FAM83A hijacked FOXM1 transcriptional regulation to promote malignant progression in lung adenocarcinoma https://doi.org/10.7717/peerj.16306 LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter https://doi.org/10.1186/s12943-023-01859-y LINC00926 promotes progression of renal cell carcinoma via regulating miR-30a-5p/SOX4 axis and activating IFNgamma-JAK2-STAT1 pathway https://doi.org/10.1016/j.canlet.2023.216463 M2 Macrophage-Derived Exosomal lncRNA MIR4435-2HG Promotes Progression of Infantile Hemangiomas by Targeting HNRNPA1 https://doi.org/10.2147/IJN.S435132 Overexpression of HSPB6 inhibits osteosarcoma progress through the ERK signaling pathway https://doi.org/10.1007/s10238-023-01216-9 PHACTR1 promotes the mobility of papillary thyroid carcinoma cells by inducing F-actin formation https://doi.org/10.1016/j.heliyon.2023.e20461 PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma https://doi.org/10.3892/or.2023.8647 RACK1 facilitates breast cancer progression by competitively inhibiting the binding of beta-catenin to PSMD2 and enhancing the stability of beta-catenin https://doi.org/10.1038/s41419-023-06191-3 Rational Design of Bioorthogonally Activatable PROTAC for Tumor-Targeted Protein Degradation https://doi.org/10.1021/acs.jmedchem.3c01423 SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFβ1/Smad signaling pathway https://doi.org/10.7150/ijbs.84591 Silencing GMPPB Inhibits the Proliferation and Invasion of GBM via Hippo/MMP3 Pathways https://doi.org/10.3390/ijms241914707 Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma https://doi.org/10.1038/s41420-023-01693-7 TBX3 promotes the epithelial mesenchymal transition of cervical cancer by upregulating ID1 https://pubmed.ncbi.nlm.nih.gov/37818083/ The role of Her-2 in penile squamous cell carcinoma progression and cisplatin chemoresistance and potential for antibody-drug conjugate-based therapy https://doi.org/10.1016/j.ejca.2023.113360 URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers https://doi.org/10.1038/s41467-023-41852-z USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress https://doi.org/10.1038/s41467-023-42257-8 WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2 https://doi.org/10.1038/s41389-023-00493-z Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression https://pubmed.ncbi.nlm.nih.gov/35235775/ Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma https://doi.org/10.1126/sciadv.adi0889 Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer https://doi.org/10.1186/s13059-023-03108-3 Epidermal-dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures https://doi.org/10.1038/s41536-023-00340-0 HILPS, a long noncoding RNA essential for global oxygen sensing in humans https://doi.org/10.1126/sciadv.adi1867 Hsa_circ_0020134 promotes liver metastasis of colorectal cancer through the miR-183-5p-PFN2-TGF-beta/Smad axis https://doi.org/10.1016/j.tranon.2023.101823 Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance https://doi.org/10.1038/s41588-023-01570-0 PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies https://doi.org/10.1158/2767-9764.CRC-23-0070 SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/beta-catenin signaling in colorectal carcinoma https://doi.org/10.1016/j.heliyon.2023.e22586 Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG https://doi.org/10.1038/s41419-023-06279-w SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma https://doi.org/10.1002/advs.202303535 Synaptotagmin 1 Suppresses Colorectal Cancer Metastasis by Inhibiting ERK/MAPK Signaling-Mediated Tumor Cell Pseudopodial Formation and Migration https://doi.org/10.3390/cancers15215282 The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity https://doi.org/10.1016/j.cmet.2023.07.005 The m(7)G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling https://doi.org/10.3390/cancers15225454 Tousled-like kinase 1 promotes gastric cancer progression by regulating the tumor growth factor-beta signaling pathway https://doi.org/10.3748/wjg.v29.i44.5919 TSTA3 overexpression promotes malignant characteristics in LUSC by regulating LAMP2-mediated autophagy and tumor microenvironment https://doi.org/10.1186/s12935-023-03109-z Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma https://doi.org/10.1186/s13148-023-01592-9 ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape https://doi.org/10.1038/s41419-023-06333-7 ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3 https://doi.org/10.1136/jitc-2023-007766 Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis https://doi.org/10.1089/dna.2023.0288 Essential genes analysis reveals small ribosomal subunit protein eS28 may be a prognostic factor and potential vulnerability in osteosarcoma https://doi.org/10.1016/j.jbo.2023.100517 Exploring the potential of carbon-coated MoSe2 nanoparticles as a photothermal therapy for ovarian cancer https://doi.org/10.1016/j.arabjc.2023.105495 HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism https://doi.org/10.1038/s41419-023-06335-5 hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma https://doi.org/10.1186/s12943-023-01887-8 Metformin Suppresses Stemness of Non-Small-Cell Lung Cancer Induced by Paclitaxel through FOXO3a https://doi.org/10.3390/ijms242316611 PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors https://doi.org/10.1158/1078-0432.CCR-23-1182 POU5F1 promotes the proliferation, migration, and invasion of gastric cancer cells by reducing the ubiquitination level of TRAF6 https://doi.org/10.1038/s41419-023-06332-8 Predictive role of E2F6 in cancer prognosis and responses of immunotherapy https://doi.org/10.1016/j.intimp.2023.111302 PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer https://doi.org/10.1186/s12951-023-02240-3 Single-particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier https://doi.org/10.1002/jev2.12395 S-Nitrosylation-mediated coupling of DJ-1 with PTEN induces PI3K/AKT/mTOR pathway-dependent keloid formation https://doi.org/10.1093/burnst/tkad024 Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1 https://doi.org/10.1158/1535-7163.MCT-22-0718 Exogenous carbon monoxide promotes GPX4-dependent ferroptosis through ROS/GSK3beta axis in non-small cell lung cancer https://doi.org/10.1038/s41420-023-01743-0 ID2 promotes tumor progression and metastasis in thyroid cancer https://doi.org/10.1007/s12020-023-03674-3 Regulation of tumor metastasis and CD8(+) T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer https://doi.org/10.1186/s11658-024-00539-z ALKBH5 is a prognostic factor and promotes the angiogenesis of glioblastoma https://doi.org/10.1038/s41598-024-51994-9 WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling https://doi.org/10.1038/s41368-024-00279-y Baicalin alleviates chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor https://doi.org/10.1016/j.jpha.2024.01.002 The miR-19a/Cylindromatosis Axis Regulates Pituitary Adenoma Bone Invasion by Promoting Osteoclast Differentiation https://doi.org/10.3390/cancers16020302 FKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2alpha blockade by facilitating LDHA phosphorylation https://doi.org/10.1038/s41419-024-06450-x Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway https://doi.org/10.1002/cnr2.1921 Jinfukang inhibits lung cancer metastasis by regulating T cell receptors https://doi.org/10.1016/j.jep.2023.116885 Enhanced Precision Therapy of Multiple Myeloma Through Engineered Biomimetic Nanoparticles with Dual Targeting https://doi.org/10.1016/j.eng.2024.01.001 Ellagic acid inhibits tumor growth and potentiates the therapeutic efficacy of sorafenib in hepatocellular carcinoma https://doi.org/10.1016/j.heliyon.2023.e23931 Targeting DAD1 gene with CRISPR-Cas9 system transmucosally delivered by fluorinated polylysine nanoparticles for bladder cancer intravesical gene therapy https://doi.org/10.7150/thno.88550 Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway https://doi.org/10.1186/s13058-023-01758-6 ZNF471 Interacts with BANP to Reduce Tumour Malignancy by Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by Aberrant Promoter Methylation in Renal Cell Carcinoma https://doi.org/10.7150/ijbs.89785 Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain https://doi.org/10.1016/j.celrep.2023.113653 Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy https://doi.org/10.1038/s41467-024-44736-y Proteomic analysis reveals LRPAP1 as a key player in the micropapillary pattern metastasis of lung adenocarcinoma https://doi.org/10.1016/j.heliyon.2023.e23913 SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFbeta1/Smad signaling pathway https://doi.org/10.7150/ijbs.84591 MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning https://doi.org/10.1186/s13578-023-01179-0 CYB561 promotes HER2+ breast cancer proliferation by inhibiting H2AFY degradation https://doi.org/10.1038/s41420-024-01804-y Superbinder based phosphoproteomic landscape revealed PRKCD_pY313 mediates the activation of Src and p38 MAPK to promote TNBC progression https://doi.org/10.1186/s12964-024-01487-z Radiotherapy-Induced Astrocyte Senescence Promotes an Immunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth https://doi.org/10.1002/advs.202304609 Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells https://doi.org/10.1186/s12964-023-01382-z Ailanthone synergizes with PARP1 inhibitor in tumour growth inhibition through crosstalk of DNA repair pathways in 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immune infiltrates and mitophagy in lung adenocarcinoma https://doi.org/10.21037/tlcr-24-344 Positive feedback loop of c-myc/XTP6/NDH2/NF-kappaB to promote malignant progression in glioblastoma https://doi.org/10.1186/s13046-024-03109-5 Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer https://doi.org/10.1007/s00018-024-05320-1 Phase separation of RNF214 promotes the progression of hepatocellular carcinoma https://doi.org/10.1038/s41419-024-06869-2 The recruitment of CD8(+) T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma https://doi.org/10.1038/s41420-024-02102-3 NOP2 facilitates EZH2-mediated epithelial-mesenchymal transition by enhancing EZH2 mRNA stability via m5C methylation in lung cancer progression https://doi.org/10.1038/s41419-024-06899-w Directed differentiation of pancreatic delta cells from human pluripotent stem cells https://doi.org/10.1038/s41467-024-50611-7 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combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling https://doi.org/10.1186/s13046-024-03168-8 USP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer https://doi.org/10.21203/rs.3.rs-4681501/v1 Single‐Cell Chromatin Accessibility Analysis Reveals Subgroup‐Specific TF‐NTR Regulatory Circuits in Medulloblastoma https://doi.org/10.1002/advs.202309554 Bioorthogonal Diels-Alder Click Chemistry-Based Pretargeted PET Imaging Strategy for Monitoring Programmed Death-Ligand 1 Expression https://doi.org/10.1021/acsomega.4c01063 RUNX1-PDIA5 Axis Promotes Malignant Progression of Glioblastoma by Regulating CCAR1 Protein Expression https://doi.org/10.7150/ijbs.92595 Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting beta2-adrenergic receptor https://doi.org/10.1016/j.jpha.2024.01.002 Polydopamine-Based Targeted Nanosystem for Chemo/Photothermal Therapy of Retinoblastoma in a Mouse Orthotopic Model https://doi.org/10.2147/IJN.S467949 DNA self-assembly-mediated high drug-antibody ratio ADC platform for targeted tumor therapy and imaging https://doi.org/10.1016/j.nantod.2024.102459 Vasorin (VASN) overexpression promotes pulmonary metastasis and resistance to adjuvant chemotherapy in patients with locally advanced rectal cancer https://doi.org/10.1186/s12967-024-05473-4 Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy https://doi.org/10.7150/thno.98574 SelK promotes glioblastoma cell proliferation by inhibiting beta-TrCP1 mediated ubiquitin-dependent degradation of CDK4 https://doi.org/10.1186/s13046-024-03157-x HDAC1 and FOXK1 mediate EGFR-TKI resistance of non-small cell lung cancer through miR-33a silencing https://doi.org/10.1186/s12967-024-05563-3 Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer https://doi.org/10.1016/j.canlet.2024.217190 Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer https://doi.org/10.1038/s43018-024-00816-y Stepwise-targeting and hypoxia-responsive liposome AMVY@NPs carrying siYAP and verteporfin for glioblastoma therapy https://doi.org/10.1186/s12951-024-02776-y Selenium-Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization https://doi.org/10.1002/advs.202402039 Three-in-One: Molecular Engineering of D-A-pi-A Featured Type I and Type II Near-Infrared AIE Photosensitizers for Efficient Photodynamic Cancer Therapy and Bacteria Killing https://doi.org/10.1002/smll.202402854 Assessments of prostate cancer cell functions highlight differences between a pan-PI3K/mTOR inhibitor, gedatolisib, and single-node inhibitors of the PI3K/AKT/mTOR pathway https://doi.org/10.1002/1878-0261.13703 ETHE1 dampens colorectal cancer angiogenesis by promoting TC45 Dephosphorylation of STAT3 to inhibit VEGF-A expression https://doi.org/10.1038/s41419-024-07021-w Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1 https://doi.org/10.1038/s41419-024-06941-x Therapeutic targeting ERRgamma suppresses metastasis via extracellular matrix remodeling in small cell lung cancer https://doi.org/10.1038/s44321-024-00108-z HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4B https://doi.org/10.1038/s41419-024-06981-3 PTBP1 knockdown impairs autophagy flux and inhibits gastric cancer progression through TXNIP-mediated oxidative stress https://doi.org/10.1186/s11658-024-00626-1 SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN https://doi.org/10.1038/s41420-024-02130-z LncRNA HOXB-AS3 promotes proliferation, migration, and invasion of gallbladder cancer cells by activating the MEK/ERK pathway https://doi.org/10.1016/j.heliyon.2024.e35906 UCK2 promotes intrahepatic cholangiocarcinoma progression and desensitizes cisplatin treatment by PI3K/AKT/mTOR/autophagic axis https://doi.org/10.1038/s41420-024-02140-x The role of BUD31 in clear cell renal cell carcinoma: prognostic significance, alternative splicing, and tumor immune environment https://doi.org/10.1007/s10238-024-01451-8 MVP enhances FGF21-induced ferroptosis in hepatocellular carcinoma by increasing lipid peroxidation through regulation of NOX4 https://doi.org/10.1111/cts.13910 MANF facilitates breast cancer cell survival under glucose-starvation conditions via PRKN-mediated mitophagy regulation https://doi.org/10.1080/15548627.2024.2392415 Engineered exosomes transporting the lncRNA, SVIL-AS1, inhibit the progression of lung cancer via targeting miR-21-5p https://doi.org/10.62347/YRJK5888 S-Doped Hollow Multi-Metallic Prussian Blue Analogue (PBA) Nanoplatform for Enhanced Anticancer for Cervical Cancer 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https://doi.org/10.3390/nano14161326 HOXA9 promotes proliferation, metastasis and prevents apoptosis in hepatocellular carcinoma https://doi.org/10.1007/s00432-024-05950-9 Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in nasopharyngeal carcinoma by stabilizing H2A https://doi.org/10.1186/s12935-024-03494-z RUNX1-MUC13 Interaction Activates Wnt/β-Catenin Signaling Implications for Colorectal Cancer Metastasis https://doi.org/10.7150/ijbs.98396 The microprotein HDSP promotes gastric cancer progression through activating the MECOM-SPINK1-EGFR signaling axis https://doi.org/10.1038/s41467-024-50986-7 Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis https://doi.org/10.1038/s41467-024-52425-z FHL2 activates β-catenin/Wnt signaling by complexing with APC and TRIM63 in lung adenocarcinoma https://doi.org/10.1016/j.tranon.2024.102131 DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K/AKT and ERK/MAPK signaling through GRB2 https://doi.org/10.1016/j.intimp.2024.113043 NEDD9 is transcriptionally regulated by HDAC4 and promotes breast cancer metastasis and macrophage M2 polarization via the FAK/NF-κB signaling pathway https://doi.org/10.1016/j.neo.2024.101059 Anlotinib reverses osimertinib resistance via inhibiting epithelial-to-mesenchymal transition and angiogenesis in non-small cell lung cancer https://doi.org/10.7555/jbr.38.20240045 SCAMP1 silencing inhibits proliferation by attenuating multiple pro-survival signaling pathways in gastric cancer https://doi.org/10.7150/jca.99610 CLK3 promotes tumor proliferation by activating MYC signaling https://doi.org/10.1186/s13008-024-00132-y Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer https://doi.org/10.1038/s44321-024-00108-z DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF‐1α Ubiquitination and Degradation https://doi.org/10.1002/advs.202308395 CircSP3 encodes SP3-461aa to promote ccRCC progression via stabilizing MYH9 and activating the PI3K-Akt signaling pathway https://doi.org/10.7150/jca.100706 Curcumin blunts epithelial-mesenchymal transition to alleviate invasion and metastasis of prostate cancer through the JARID1D demethylation https://doi.org/10.1186/s12935-024-03483-2 Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors https://doi.org/10.1016/j.redox.2024.103350 Combined miR-181a-5p and Ag Nanoparticles are Effective Against Oral Cancer in a Mouse Model https://doi.org/10.2147/ijn.S458484 Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production https://doi.org/10.1038/s41419-024-07068-9 PBA2, a novel inhibitor of the β-catenin/CBP pathway, eradicates chronic myeloid leukemia including BCR-ABL T315I mutation https://doi.org/10.1186/s12943-024-02129-1 MYO3B promotes cancer progression in endometrial cancer by mediating the calcium ion-RhoA/ROCK1 signaling pathway https://doi.org/10.1007/s00432-024-05940-x Lanthanum-based dendritic mesoporous nanoplatform for tumor microenvironment activating synergistic anti-glioma efficacy https://doi.org/10.1016/j.mtbio.2024.101223 PIM1 kinase promotes EMT-associated osimertinib resistance via regulating GSK3β signaling pathway in EGFR-mutant non-small cell lung cancer https://doi.org/10.1038/s41419-024-07039-0 Chlorogenic acid exhibits antitumor effect in patient-derived xenograft models and hydrogel-embedded tissue culture drug susceptibility test of tongue cancer https://doi.org/10.1016/j.heliyon.2024.e37523 LMP1 enhances aerobic glycolysis in natural killer/T cell lymphoma https://doi.org/10.1038/s41419-024-06999-7 ACSL6-activated IL-18R1–NF-κB promotes IL-18–mediated tumor immune evasion and tumor progression. https://doi.org/10.1126/sciadv.adp071 Enhanced tumor targeting and penetration of fluorophores via iRGD peptide conjugation: a strategy for the precision targeting of lung cancer https://doi.org/10.21037/tlcr-24-589 METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma https://doi.org/10.1186/s13045-024-01599-6 DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models https://doi.org/10.1186/s12967-024-05568-y DAP3 promotes mitochondrial activity and tumour progression in hepatocellular carcinoma by regulating MT-ND5 expression https://doi.org/10.1038/s41419-024-06912-2 Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC https://doi.org/10.1016/j.jare.2024.08.021 Nanobody-Engineered Biohybrid Bacteria Targeting Gastrointestinal Cancers Induce Robust STING-Mediated Anti-Tumor Immunity https://doi.org/10.1002/advs.202401905 Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity https://doi.org/10.1016/j.celrep.2024.114762 FABP4-mediated lipid metabolism promotes TNBC progression and breast cancer stem cell activity https://doi.org/10.1016/j.canlet.2024.217271
*使用本品系发表的文献需注明：BALB/c-Nude mice（Strain NO.D000521）were purchased from GemPharmatech (Nanjing, China).
